What is this medicine?

ELBASVIR; GRAZOPREVIR (el' bas vir; graz oh' pre vir) is two antiviral medicines in one tablet. It is used to treat hepatitis C. It will not work for colds, flu, or other viral infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): ZEPATIER

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • diabetes
  • HIV or AIDS
  • other liver disease
  • an unusual or allergic reaction to elbasvir, grazoprevir, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. You can take it with or without food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain antiviral medicines for HIV or AIDS like atazanavir, darunavir, efavirenz, lopinavir, saquinavir, tipranavir
  • certain medicines for seizures like carbamazepine, phenytoin
  • cyclosporine
  • rifampin
  • St. John's Wort

This medicine may also interact with the following medications:

  • bosentan
  • certain antiviral medicines for HIV or AIDS like cobicistat; elvitegravir; emtricitabine; tenofovir, and etravirine
  • certain medicines for cholesterol like atorvastatin, fluvastatin, lovastatin, rosuvastatin, and simvastatin
  • certain medicines for diabetes
  • ketoconazole
  • modafinil
  • nafcillin
  • tacrolimus
  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

See your doctor or health care professional for a follow-up visit as directed. You may need blood work while you are taking this medicine. Tell your doctor if your symptoms do not improve or if they get worse.

If you have had hepatitis B infection (HBV) in the past, taking this medicine could cause the HBV to become active again. If you have had HBV, your doctor should monitor you with blood tests. Tell your doctor right away if you develop a general ill feeling, light-colored stools, loss of appetite, unusual weakness, or yellowing of the eyes or skin.

This medicine may cause changes in your blood sugar. Ask your health care provider if changes in diet or medicines are needed if you have diabetes.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; vomiting; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • nausea
  • tiredness
  • trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 20 to 25 degrees C (68 to 77 degrees F). Throw away any unused medicine after the expiration date

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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