Locations:

Secukinumab Injection

Secukinumab is a medication that treats psoriasis. This autoimmune condition causes inflammation in your skin that appears as thick areas of discolored skin covered with scales (plaques). A healthcare provider can give you this injection or they’ll teach you how to give this medication to yourself at home.

What is this medication?

SECUKINUMAB (sek ue KIN ue mab) treats autoimmune conditions, such as arthritis and psoriasis. It works by slowing down an overactive immune system.  It may also be used to treat hidradenitis suppurativa (HS). HS is a condition that causes painful lumps under the skin in areas such as the armpits and groin. It is a monoclonal antibody.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Cosentyx

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Crohn's disease, ulcerative colitis, or other inflammatory bowel disease
  • Immune system problems
  • Infection or history of infection, such as a viral infection, chickenpox, cold sores, or herpes
  • Recently received or are scheduled to receive a vaccine
  • Tuberculosis, a positive skin test for tuberculosis, or recent close contact with someone who has tuberculosis
  • An unusual or allergic reaction to secukinumab, latex, rubber, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is injected into a vein or under the skin. It is given by your care team in a hospital or clinic setting if it is injected into a vein. If it is injected under the skin, it may be given at home.

If you get this medication at home, you will be taught how to prepare and give it. Use it exactly as directed. Take it as directed on the prescription label. Keep taking it unless your care team tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

Advertisement

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you get this medication at the hospital or clinic: It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

If you give yourself this medication at home: If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Call your care team with questions.

What may interact with this medication?

  • Live virus vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

You will be tested for tuberculosis (TB) before you start this medication. If your care team prescribes any medication for TB, you should start taking the TB medication before starting this medication. Make sure to finish the full course of TB medication.

This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.

This medication can decrease the response to a vaccine. If you need to get vaccinated, tell your care team if you have received this medication within the last 6 months. Extra booster doses may be needed. Talk to your care team to see if a different vaccination schedule is needed.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dry, itchy, scaly patches of skin that blister or peel
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting

Advertisement

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Diarrhea
  • Runny or stuffy nose
  • Sore throat

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store in the refrigerator. Do not freeze. Keep it in the original carton until you are ready to use it. Protect from light. Do not shake. Remove the dose from the refrigerator about 30 minutes before it is time for you to use it. Use it within 4 days of removing it from the carton. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Advertisement

Copyright ©2025 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

Ad