PROMETHAZINE (proe METH a zeen) prevents and treats the symptoms of an allergic reaction. It works by blocking histamine, a substance released by the body during an allergic reaction. It may also help you relax, go to sleep, and relieve nausea, vomiting, or pain before or after procedures. It can also treat motion sickness. It works by helping your nervous system calm down by blocking substances in the body that may cause nausea and vomiting. It belongs to a group of medications called antihistamines.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Anergan-50, Pentazine, Phenergan
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They need to know if you have any of these conditions:
This medication is for injection into a muscle, or into a vein. It is given in a hospital or clinic setting.
Talk to your care team about the use of this medication in children. This medication should not be given to infants and children younger than 2 years old.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
This does not apply.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Your condition will be monitored carefully while you are receiving this medication.
Your care team will discuss with you the risks and the benefits of using this medication. This medication has caused serious side effects in some patients after it was injected into a vein. Watch closely for any signs or symptoms of a local reaction like burning, pain, redness, swelling, and blistering and tell your care team immediately if any occur. These symptoms may occur when you receive the injection or may occur hours or even days after the injection.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. To reduce the risk of dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older patient. Alcohol may increase dizziness and drowsiness. Avoid alcoholic drinks.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help.
This medication may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your care team if the problem does not go away or is severe.
Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths.
This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
This medication is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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Note: Introduction and Frequently Asked Questions written and medically approved by Cleveland Clinic professionals.