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Doxycycline Injection

Doxycycline injections treat and prevent a wide range of bacterial infections. They’re a common antibiotic that treats conditions like acne, urinary tract infections, intestinal infections, respiratory infections and others.

What is this medication?

DOXYCYCLINE (dox i SYE kleen) treats infections caused by bacteria. It belongs to a group of medications called tetracycline antibiotics. It will not treat colds, the flu, or infections caused by viruses.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Doxy 100

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Kidney disease
  • Liver disease
  • Long exposure to sunlight like working outdoors
  • Recent stomach surgery
  • Stomach or intestine problems such as colitis
  • Vision Problems
  • Yeast or fungal infection of the mouth or vagina
  • An unusual or allergic reaction to doxycycline, tetracycline antibiotics, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is injected into a vein. It is given by your care team in a hospital or clinic.

Talk to your care team regarding the use of this medication in children. While this medication may be prescribed for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medication?

  • Barbiturates
  • Birth control pills
  • Carbamazepine
  • Methoxyflurane
  • Oral retinoids such as acitretin, isotretinoin
  • Other antibiotics
  • Phenytoin
  • Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Tell your care team if your symptoms do not improve.

Do not treat diarrhea with over the counter products. Contact your care team if you have diarrhea that lasts more than 2 days or if it is severe and watery.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

If you are being treated for a sexually transmitted infection, avoid sexual contact until you have finished your treatment. Your sexual partner may also need treatment.

Birth control pills may not work properly while you are taking this medication. Talk to your care team about using an extra method of birth control.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Increased pressure around the brain—severe headache, change in vision, blurry vision, nausea, vomiting
  • Joint pain
  • Pain or trouble swallowing
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Severe diarrhea, fever
  • Unusual vaginal discharge, itching, or odor

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Change in tooth color
  • Diarrhea
  • Headache
  • Heartburn
  • Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This does not apply. You will only receive this medication in a hospital or clinic.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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