Leflunomide is a medication that treats rheumatoid arthritis. Rheumatoid arthritis occurs when your immune system attacks the tissue lining the joints on both sides of your body. The brand name of this medication is Arava®. You can take this medication by mouth with a glass of water as directed.
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LEFLUNOMIDE (le FLOO na mide) treats the symptoms of rheumatoid arthritis. It works by slowing down an overactive immune system. This decreases inflammation. It belongs to a group of medications called DMARDs.
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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Arava
They need to know if you have any of these conditions:
Take this medication by mouth with a full glass of water. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
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Do not take this medication with any of the following:
This medication may also interact with the following:
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. You may need blood work done while you are taking this medication.
This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms.
You should not receive certain vaccines during your treatment and for a certain time after your treatment with this medication ends. Talk to your care team for more information.
This medication may stay in your body for up to 2 years after your last dose. Tell your care team about any unusual side effects or symptoms. A medication can be given to help lower your blood levels of this medication more quickly.
Talk to your care team if you may be pregnant. This medication can cause serious birth defects if taken during pregnancy and for a while after the last dose. You will need a negative pregnancy test before starting this medication. Contraception is recommended while taking this medication and for a while after the last dose. Your care team can help you find the option that works for you.
Do not breastfeed while taking this medication.
Side effects that you should report to your care team as soon as possible:
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Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture and light. Keep the container tightly closed. Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.