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Chlorthalidone Tablets

Chlorthalidone is a diuretic medication that treats high blood pressure. It also treats swelling caused by heart, kidney or liver disease. It works by helping your kidneys remove fluid and salt from your blood through your pee. The brand name of this medication is Thalitone®.

What is this medication?

CHLORTHALIDONE (klor THAL i done) treats high blood pressure. It may also be used to reduce swelling related to heart, kidney, or liver disease. It helps your kidneys remove more fluid and salt from your blood through urine. It belongs to a group of medications called diuretics.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Thalitone

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Diabetes, high blood sugar
  • Gout
  • Kidney disease
  • Liver disease
  • Lung or breathing disease (asthma)
  • Lupus
  • An unusual or allergic reaction to chlorthalidone, sulfa medications, other medications, foods, dyes or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. Take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

  • Barbiturate medications for sleep or seizure control
  • Digoxin
  • Lithium
  • Medications for diabetes
  • Norepinephrine
  • Other medications for high blood pressure
  • Some pain medications
  • Steroid hormones like prednisone, cortisone, hydrocortisone, corticotropin
  • Tubocurarine

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This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Ask your care team what your blood pressure should be. Also, find out when you should contact him or her.

Check with your care team if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medication.

You may need to be on a special diet while you are taking this medication. Ask your care team. Also, find out how many glasses of fluids you need to drink each day.

Do not treat yourself for coughs, colds, or pain while you are using this medication without asking your care team for advice. Some medications may increase your blood pressure.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medication. Avoid alcoholic drinks.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
  • Gout—severe pain, redness, warmth, or swelling in joints, such as the big toe
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
  • Sudden eye pain or change in vision such as blurred vision, seeing halos around lights, vision loss

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Change in sex drive or performance
  • Headache
  • Upset stomach

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from light. Throw away any unused medication after the expiration date.

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NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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