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Romiplostim Injection

Romiplostim helps your body make more platelets. These are the smallest component of your blood that control bleeding. This medication treats chronic idiopathic thrombocytopenic purpura. This is a blood condition that occurs when you don’t have enough platelets. A healthcare provider will give you this injection in a hospital or clinic setting.

What is this medication?

ROMIPLOSTIM (roe mi PLOE stim) treats low levels of platelets in your body caused by immune thrombocytopenia (ITP). It is prescribed when other medications have not worked or cannot be tolerated. It may also be used to help people who have been exposed to high doses of radiation. It works by increasing the amount of platelets in your blood. This lowers the risk of bleeding.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Nplate

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Blood clots
  • Myelodysplastic syndrome
  • An unusual or allergic reaction to romiplostim, mannitol, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is injected under the skin. It is given by a care team in a hospital or clinic setting.

A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as newborns for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You may need blood work done while you are taking this medication. Your condition will be monitored carefully while you are receiving this medication. It is important not to miss any appointments.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Dizziness
  • Joint pain
  • Muscle pain
  • Pain in the hands or feet
  • Stomach pain
  • Trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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