Immune Globulin; Hyaluronidase Injection

What is this medication?

IMMUNE GLOBULIN; HYALURONIDASE (im MUNE GLOB yoo lin; hye al ur ON i dase) treats primary immunodeficiency (PI), a condition that weakens the immune system. It works by giving your body extra antibodies. Antibodies are proteins made by the immune system that help protect the body.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): HYQVIA

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Dehydration
• Diabetes
• Heart disease
• History of blood clots
• Kidney disease
• Low IgA levels in the blood
• An unusual or allergic reaction to immune globulin, hyaluronidase, other blood products, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

How should I use this medication?

This medication is injected under the skin. It is usually given by your care team in a hospital or clinic setting. It may also be given at home.

If you get this medication at home, you will be taught how to prepare and give it. Use exactly as directed. Take it as directed on the prescription label. Keep taking it unless your care team tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you get this medication at the hospital or clinic: It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

If you give yourself this medication at home: If you miss a dose, take it as soon as you can. Then continue your normal schedule. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Call your care team with questions.

What may interact with this medication?

• Live virus vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

You may need blood work while taking this medication.

Call your care team if you are around anyone with measles or if you develop sores or blisters that do not heal properly.

This medication is made from human blood. It may be possible to pass an infection in this medication. Talk to your care team about the risks and benefits of this medication.

This medication can decrease the response to a vaccine. If you need to get vaccinated, tell your care team if you have received this medication. Extra booster doses may be needed Talk to your care team to see if a different vaccination schedule is needed.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
• Fever, neck pain or stiffness, sensitivity to light, headache, nausea, vomiting, confusion, which may be signs of meningitis
• Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
• Lung injury—shortness of breath or trouble breathing, cough, spitting up blood, chest pain, fever

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Fatigue
• Fever
• Nausea
• Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

If you are using this medication at home, you will be instructed on how to store this medication. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.