What is this medicine?

HYDROCHLOROTHIAZIDE; PROPRANOLOL (hye droe klor oh THYE a zide; proe PRAN oh lole) is a combination of a diuretic and a beta-blocker. It is used to treat high blood pressure.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Inderide

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • circulation problems, or blood vessel disease
  • decreased urine
  • diabetes
  • gout
  • heart disease
  • immune system problems
  • kidney disease
  • liver disease
  • lung or breathing disease, like asthma
  • pheochromocytoma
  • thyroid disease
  • an unusual or allergic reaction to this hydrochlorothiazide, propranolol, sulfa drugs, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on your prescription label. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

This medicine may also interact with the following medications:

  • aluminum hydroxide gel
  • antipyrine
  • barbiturates like phenobarbital
  • chlorpromazine
  • cimetidine
  • haloperidol
  • lidocaine
  • lithium
  • medicines for diabetes
  • medicines that relax muscles for surgery
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • phenytoin
  • reserpine
  • rifampin
  • steroid medicines like prednisone or cortisone
  • theophylline
  • thyroid medicines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions such as skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat
  • breathing problems
  • changes in vision
  • chest pain
  • eye pain
  • fast or irregular heartbeat
  • feeling faint or lightheaded, falls
  • gout attack
  • muscle pain or cramps
  • pain or difficulty when passing urine
  • pain, tingling, numbness in the hands or feet
  • redness, blistering, peeling or loosening of the skin, including inside the mouth

signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision.

  • slow heart rate
  • swelling of the legs and ankles
  • unusually weak

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive or performance
  • diarrhea
  • dry mouth
  • hair loss
  • headache
  • stomach upset

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture, freezing, and excessive heat. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2020 Elsevier Inc. All Rights Reserved. Terms of Use.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy