Voretigene neparvovec injection

Voretigene neparvovec injection treats inherited retinal disease (IRD) due to mutations in both copies of the RPE65 gene. It’s a type of gene therapy your provider gives you in one dose through a needle in your retina.

What is this medication?

VORETIGENE NEPARVOVEC (vor ET i jeen ne PAR voe vek) is a gene therapy used to treat a certain form of inherited vision loss.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): LUXTURNA

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • eye disease, vision problems
  • an unusual or allergic reaction to voretigene neparvovec, other medicines, foods, dyes, or preservative
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

This medicine is for injection into the eye. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 1 year for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine.

Tell your doctor or health care professional right away if you have any change in your eyesight.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • bleeding from the eye
  • changes in vision
  • eye pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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