Conivaptan Injection

What is this medication?

CONIVAPTAN (con i VAP tan) is a diuretic. It helps you make more urine and to lose excess water from your body. It treats low sodium blood levels.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Vaprisol, Vaprisol in Dextrose

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• heart disease
• kidney disease
• liver disease
• low blood pressure
• an unusual or allergic reaction to conivaptan, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This drug is injected into a vein. It is given by a health care provider in a hospital or clinic setting.

Talk to your health care provider about the use of this drug in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This drug is not for regular use.

What may interact with this medication?

Do not take this medicine with any of the following medications:

• alfuzosin
• antiviral medicines for HIV or AIDS
• certain antibiotics like chloramphenicol, clarithromycin, dalfopristin; quinupristin, telithromycin
• certain medicines for fungal infections like ketoconazole, isavuconazonium, itraconazole, posaconazole, voriconazole
• cisapride
• eletriptan
• eplerenone
• ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
• flibanserin
• idelalisib
• ivabradine
• lomitapide
• lurasidone
• mifepristone, RU-486
• naloxegol
• nefazodone
• ranolazine
• simvastatin

This medicine may also interact with the following medications:

• brigatinib
• cabozantinib
• copanlisib
• deferasirox
• digoxin
• erlotinib
• fluticasone
• ibrutinib
• midostaurin
• neratinib
• nimodipine
• panobinostat
• paricalcitol
• ponatinib
• ribociclib
• suvorexant
• topotecan
• trabectedin
• venetoclax
• vilanterol
• vorapaxar
• warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• chest pain
• confusion
• fast, irregular heartbeat
• feeling faint or lightheaded, falls
• fever
• low blood pressure
• swelling, pain at site where injected
• swelling of the ankles, feet, hands
• unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• constipation
• diarrhea
• dry mouth
• headache
• nausea
• thirst
• trouble sleeping
• vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.