Ivabradine Tablets

What is this medication?

IVABRADINE (eye VAB ra deen) treats heart failure. It works by decreasing your heart rate, which decreases the amount of work your heart has to do.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Corlanor

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Certain heart conditions, such as sick sinus syndrome, sinoatrial block, or third-degree atrioventricular block
• Heart failure that has recently worsened
• Liver disease
• Low blood pressure
• Low resting heart rate
• Pacemaker
• An unusual or allergic reaction to ivabradine, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the prescription label at the same time every day. Take it with food. Avoid grapefruit juice. Keep taking it unless your care team tells you to stop.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 6 months for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, skip it. Take your next dose at the normal time. Do not take extra or 2 doses at the same time to make up for the missed dose.

What may interact with this medication?

Do not take this medication with any of the following:

• Adagrasib
• Ceritinib
• Certain antibiotics, such as chloramphenicol, clarithromycin, telithromycin
• Certain antivirals for HIV or hepatitis
• Certain medications for fungal infections, such as ketoconazole, itraconazole, posaconazole, voriconazole
• Idelalisib
• Lonafarnib
• Nefazodone
• Ribociclib
• Tucatinib

This medication may also interact with the following:

• Certain medications for blood pressure, heart disease, irregular heartbeat
• Certain medications for seizures, such as phenobarbital or phenytoin
• Rifampin
• St. John's wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

You may experience changes in vision. Use caution if you are driving or using machinery when sudden changes in light intensity may occur, especially while driving at night. This effect may decrease after using this medication for a long time.

Talk to your care team if you wish to become pregnant or think you may be pregnant. This medication can cause serious birth defects.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
• Increase in blood pressure
• Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
• Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Luminous phenomena—seeing temporary bright or flashing spots, halos around lights, shifting patterns or colors

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.