What is this medication?

RISPERIDONE (ris PER i done) is an antipsychotic. It is used to treat schizophrenia, bipolar disorder, and some symptoms of autism.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Risperdal

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • dementia
  • diabetes
  • difficulty swallowing
  • have trouble controlling your muscles
  • heart disease
  • high cholesterol
  • high levels of prolactin
  • history of breast cancer
  • history of irregular heartbeat
  • history of stroke
  • kidney disease
  • liver disease
  • low blood counts, like low white cell, platelet, or red cell counts
  • low blood pressure
  • Parkinson's disease
  • seizures
  • an unusual or allergic reaction to risperidone, paliperidone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 5 years of age for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medicine with any of the following medications:

  • cisapride
  • dextromethorphan; quinidine
  • dronedarone
  • metoclopramide
  • pimozide
  • quinidine
  • thioridazine

This medicine may also interact with the following medications:

  • alcohol
  • antihistamines for allergy, cough, and cold
  • certain medicines for anxiety or sleep
  • certain medicines for depression like amitriptyline, fluoxetine, paroxetine, sertraline
  • general anesthetics like halothane, isoflurane, methoxyflurane, propofol
  • levodopa or other medicines for Parkinson's disease
  • medicines for blood pressure
  • medicines for seizures
  • medicines that relax muscles for surgery
  • methylphenidate
  • narcotic medicines for pain
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • phenothiazines like chlorpromazine, prochlorperazine
  • rifampin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your health care professional for regular checks on your progress. Tell your health care professional if symptoms do not start to get better or if they get worse. Do not stop taking except on your health care professional's advice. You may develop a severe reaction. Your health care professional will tell you how much medicine to take.

You may get dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This drug can cause problems with controlling your body temperature. It can lower the response of your body to cold temperatures. If possible, stay indoors during cold weather. If you must go outdoors, wear warm clothes. It can also lower the response of your body to heat. Do not overheat. Do not over-exercise. Stay out of the sun when possible. If you must be in the sun, wear cool clothing. Drink plenty of water. If you have trouble controlling your body temperature, call your health care provider right away.

This medicine may increase blood sugar. Ask your health care provider if changes in diet or medicines are needed if you have diabetes.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breast enlargement in both males and females
  • breathing problems
  • confusion
  • fast, irregular heartbeat
  • fever or chills, sore throat
  • inability to keep still
  • males: prolonged or painful erection
  • missed menstrual periods
  • problems with balance, talking, walking
  • redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • seizures
  • signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal. You may also feel very tired or have blurry vision
  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired
  • signs and symptoms of neuroleptic malignant syndrome like confusion; fast or irregular heartbeat; high fever; increased sweating; stiff muscles
  • sudden numbness or weakness of the face, arm, or leg
  • suicidal thoughts or other mood changes
  • trouble swallowing
  • uncontrollable movements of the arms, face, head, mouth, neck, or upper body

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in sex drive or performance
  • constipation
  • drowsiness
  • dry mouth
  • upset stomach
  • weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Protect from light. Get rid of any unused medicine after the expiration date.

To get rid of medicines that are no longer needed or have expired:

  • Take the medicine to a medicine take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medicine, check the label or package insert to see if the medicine should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your health care provider. If it is safe to put it in the trash, take the medicine out of the container. Mix the medicine with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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