Promethazine; Phenylephrine Solution

What is this medication?

PROMETHAZINE; PHENYLEPHRINE (proe METH a zeen; fen il EF rin) treats the symptoms of the common cold, allergies, or flu. It works by reducing red, itchy eyes and a runny or stuffy nose. It is a combination of an antihistamine and a decongestant.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Phen-Tuss AD, Prometh VC Plain

What should I tell my care team before I take this medication?

They need to know if you have any of the following conditions:

• Diabetes
• Enlarged prostate
• Glaucoma
• Heart disease
• Liver disease
• Seizure disorder
• Serious illness
• Sleep apnea
• Thyroid disease
• Trouble passing urine
• Ulcer or other stomach problem
• An unusual or allergic reaction to promethazine, phenylephrine, phenothiazines, sulfites, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Use a specially marked spoon or container to measure your medication. Household spoons are not accurate. Take your doses at regular intervals. Do not take your medication more often than directed.

Talk to your care team regarding the use of this medication in children. While this medication may be prescribed for children as young as 2 years of age for selected conditions, precautions do apply. Do not use in children under 2 years old.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

• Bromocriptine
• Cocaine
• Disopyramide
• Ergotamine, dihydroergotamine
• MAOIs, such as Carbex, Eldepryl, Marplan, Nardil, and Parnate
• Procarbazine
• Risperidone
• Stimulant drugs

This medication may also interact with the following:

• Alcohol
• Barbiturate medications, such as phenobarbital
• Cabergoline
• Caffeine
• Diet aids
• Epinephrine
• Heart medications
• Linezolid
• Medications for asthma
• Medications for cold or allergies
• Medications for depression, anxiety, or other mental health conditions
• Medications for Parkinson disease
• Medications for sleep
• Medications for the stomach, such as metoclopramide, dicyclomine, glycopyrrolate
• Oxytocin
• Pain medications
• Radio contrast dyes
• St. John's Wort
• Theophylline

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not improve or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medication. Avoid alcoholic drinks.

This medication may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye care team if the problem does not go away or is severe.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake
• Heart palpitations—rapid, pounding, or irregular heartbeat
• High fever, stiff muscles, increased sweating, fast or irregular heartbeat, and confusion, which may be signs of neuroleptic malignant syndrome
• Increase in blood pressure
• Infection—fever, chills, cough, or sore throat
• Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
• Trouble passing urine
• Uncontrolled and repetitive body movements, muscle stiffness or spasms, tremors or shaking, loss of balance or coordination, restlessness, shuffling walk, which may be signs of extrapyramidal symptoms (EPS)

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Anxiety, nervousness
• Confusion
• Constipation
• Dizziness
• Drowsiness
• Dry mouth
• Headache
• Trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Protect from light. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.