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Gefitinib Tablets

Gefitinib works to stop cancer cells from growing to treat advanced non-small cell lung cancer. This type of cancer causes cancer cells to grow slowly in your lung tissues. This medication comes in a tablet form that you can take by mouth with water as directed. You can take it with or without food.

What is this medication?

GEFITINIB (ge FI ti nib) treats lung cancer. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Iressa

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Eye disease
  • Liver disease
  • Lung or breathing disease, such as asthma or COPD
  • Recent or ongoing radiation
  • Scarring or thickening of the lungs
  • Vision problems
  • An unusual or allergic reaction to gefitinib, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with a full glass of water. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can unless it is less than 12 hours before the next dose. If it is less than 12 hours before the next dose, skip the missed dose. Take the next dose at the normal time.

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What may interact with this medication?

Do not take this medication with any of the following:

  • Thioridazine

This medication may also interact with the following:

  • Antacids
  • Certain antivirals for HIV or AIDS
  • Certain medications for fungal infections, such as ketoconazole, itraconazole
  • Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin
  • Certain medications for stomach problems, such as cimetidine, famotidine, omeprazole, lansoprazole
  • Certain medications that prevent or treat blood clots, such as warfarin
  • Rifampin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. It may be some time before you see the benefit from this medication.

You may need blood work while taking this medication.

Check with your care team if you have severe diarrhea, nausea, and vomiting, or if you sweat a lot. The loss of too much body fluid may make it dangerous for you to take this medication.

This medication may cause severe lung problems. Call your care team if your breathing gets worse and/or you develop a cough or fever.

Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects if taken during pregnancy or for 2 weeks after the last dose. A reliable form of contraception is recommended while taking this medication and for 2 weeks after the last dose. Talk to your care team about reliable forms of contraception.

Do not breast-feed while taking this medication.

This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dry cough, shortness of breath or trouble breathing
  • Eye pain, redness, irritation, or discharge with blurry or decreased vision
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Severe or prolonged diarrhea
  • Stomach pain that is severe, does not go away, or gets worse

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

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  • Acne
  • Change in nail shape, thickness, or color
  • Dry skin
  • Loss of appetite
  • Pain, redness, or swelling with sores inside the mouth or throat
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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