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Rotigotine Patches

Rotigotine is a medication that treats the symptoms of Parkinson’s disease. This is a degenerative brain condition that causes slowed movements, tremors and balance problems. Follow the instructions on the label to use this patch on your skin as directed.

What is this medication?

ROTIGOTINE (roe TIG oh teen) treats the symptoms of Parkinson disease. It works by acting like dopamine, a substance in your body that helps manage movements and coordination. This reduces the symptoms of Parkinson, such as body stiffness and tremors. It may also be used to treat restless legs syndrome (RLS).

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Neupro

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Heart disease
  • High blood pressure
  • Low blood pressure
  • Kidney disease
  • Mental health condition
  • Narcolepsy
  • Sleep apnea
  • An unusual or allergic reaction to rotigotine, sulfites, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for external use only. Use it as directed on the prescription label. Change the patch each day at the same time. Always remove the old patch before you apply a new one. Wash hands after removing and applying this medication. Keep using it unless your care team tells you to stop.

This medication comes with INSTRUCTIONS FOR USE. Ask your pharmacist for directions on how to use this medication. Read the information carefully. Talk to your pharmacist or care team if you have questions.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

  • Alcohol
  • Antihistamines for allergy, cough, and cold
  • Certain medications for sleep
  • Medications for depression, anxiety, or mental health conditions
  • Metoclopramide
  • Opioid medications for pain

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

Do not suddenly stop taking this medication. You may develop a severe reaction. Your care team will tell you how much medication to take. If your care team wants you to stop the medication, the dose may be slowly lowered over time to avoid any side effects.

This medication may affect your coordination, reaction time, or judgement. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

When taking this medication, you may fall asleep without notice. You may be doing activities like driving a car, talking, or eating. You may not feel drowsy before it happens. Contact your care team right away if this happens to you.

There have been reports of increased sexual urges or other strong urges, such as gambling while taking this medication. If you experience any of these while taking this medication, you should report this to your care team as soon as possible.

This patch is sensitive to certain body heat changes. If your skin gets too hot, more medication will come out of the patch and can cause a deadly overdose. Call your care team if you get a fever. Do not take hot baths. Do not sunbathe. Do not use hot tubs, saunas, hairdryers, heating pads, electric blankets, heated waterbeds, or tanning lamps. Do not do exercise that increases your body temperature.

If you are going to have a magnetic resonance imaging (MRI) procedure, tell your MRI technician if you have this patch on your body. It must be removed before a MRI.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Falling asleep during daily activities
  • Fast or irregular heartbeat
  • Hallucinations
  • Increase in blood pressure
  • Irritation at application site
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Mood swings, irritability, hostility
  • New or worsening uncontrolled and repetitive movements of the face, mouth, or upper body
  • Swelling of the ankles, hands, or feet
  • Urges to engage in impulsive behaviors such as gambling, binge eating, sexual activity, or shopping in ways that are unusual for you

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Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Confusion
  • Dizziness
  • Drowsiness
  • Headache
  • Excessive sweating
  • Nausea
  • Trouble sleeping
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Store in original pouch until just before use. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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