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Methadone Tablets

Methadone is an opioid medication that treats severe, chronic pain and substance use disorder. A healthcare provider will prescribe this medication to you if other pain medications don’t work. It blocks pain signals in your brain.

What is this medication?

METHADONE (METH a done) treats severe, chronic pain. It is often prescribed when other treatment options have not worked well enough or cannot be tolerated. It works by blocking pain signals in the brain. It may also be used to treat opioid use disorder. It works by blocking the effect of opioids and reducing cravings to use opioids. It is most effective when used in combination with counseling and behavior therapy. It belongs to a group of medications called opioids.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Dolophine, Methadose

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Alcohol use
  • Bile duct or gallbladder problems
  • Bowel blockage
  • Brain tumor
  • Diabetes
  • Head injury
  • Heart disease
  • Heart failure
  • High or low levels of electrolytes, such as magnesium or potassium, in your blood
  • Irregular heartbeat or rhythm
  • Kidney disease
  • Liver disease
  • Low adrenal gland function
  • Low blood pressure
  • Lung or breathing disease, such as asthma or COPD
  • Mental health conditions
  • Pancreatitis
  • Seizures
  • Slow heartbeat
  • Substance use disorder
  • An unusual or allergic reaction to methadone, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. Special care may be needed.

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Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Certain medications for fungal infections, such as itraconazole, ketoconazole, posaconazole, voriconazole
  • Certain medications for irregular heartbeat, such as bepridil, bretylium, dronedarone, quinidine
  • Cisapride
  • Halofantrine
  • Mesoridazine
  • Pimozide
  • Rasagiline
  • Selegiline
  • Thioridazine

This medication may also interact with the following:

  • Alcohol
  • Antihistamines for allergy, cough, and cold
  • Antiviral medications for HIV or AIDS
  • Arsenic trioxide
  • Atropine
  • Certain antibiotics, such as clarithromycin, erythromycin, gemifloxacin, levofloxacin, moxifloxacin, ofloxacin, pentamidine, telithromycin, rifampin, rifapentine
  • Certain medications for anxiety or sleep
  • Certain medications for bladder problems, such as oxybutynin, tolterodine
  • Certain medications for cancer, such as dasatinib, lapatinib, sunitinib, vorinostat
  • Certain medications for depression, such as amitriptyline, desipramine, fluoxetine, sertraline
  • Certain medications for irregular heartbeat, such as amiodarone, disopyramide, flecainide, procainamide, propafenone, sotalol
  • Certain medications for malaria, such as chloroquine, mefloquine
  • Certain medications for migraine headache, such as almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • Certain medications for nausea or vomiting, such as dolasetron, droperidol, granisetron, ondansetron
  • Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin, primidone
  • Certain medications for stomach problems, such as dicyclomine, hyoscyamine
  • Certain medications for travel sickness, such as scopolamine
  • Certain medications for Parkinson's disease, such as benztropine, trihexyphenidyl
  • Fluconazole
  • General anesthetics, such as halothane, isoflurane, methoxyflurane, propofol
  • Haloperidol
  • Ipratropium
  • Linezolid
  • Local anesthetics, such as lidocaine, pramoxine, tetracaine
  • MAOIs, such as Marplan, Nardil, and Parnate
  • Medications that relax muscles for surgery
  • Methylene blue
  • Octreotide
  • Other medications that cause heart rhythm changes
  • Other opioid medications for pain or cough
  • Peginterferon alfa-2b
  • Phenothiazines, such as chlorpromazine, prochlorperazine
  • Ranolazine
  • Tacrolimus
  • Vardenafil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

If you are using this medication for pain, tell your care team if your pain does not go away, if it gets worse, or if you have new or a different type of pain. You may develop tolerance to this medication. Tolerance means that you will need a higher dose of the medication for pain relief. Tolerance is normal and is expected if you take this medication for a long time.

If you are using this medication for opioid use disorder, visit your care team regularly. For this medication to be most effective, you should attend any counseling or support groups that your care team recommends. Do not try to overcome the effects of the medication by taking large amounts of opioids. This can cause severe problems including death. Also, you may be more sensitive to lower doses of opioids after you stop taking this medication.

Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card.

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Taking this medication with other substances that cause drowsiness, such as alcohol, benzodiazepines, or other opioids can cause serious side effects. Give your care team a list of all medications you use. They will tell you how much medication to take. Do not take more medication than directed. Call emergency services if you have problems breathing or staying awake.

Children may be at higher risk for side effects. Stop giving this medication and call emergency services right away if your child has slow or noisy breathing, has confusion, is unusually sleepy, or not able to wake up.

Long term use of this medication may cause your brain and body to depend on it. This can happen even when used as directed by your care team. You and your care team will work together to determine how long you will need to take this medication. If your care team wants you to stop this medication, the dose will be slowly lowered over time to reduce the risk of side effects.

Naloxone is an emergency medication used for an opioid overdose. An overdose can happen if you take too much of an opioid. It can also happen if an opioid is taken with some other medications or substances such as alcohol. Know the symptoms of an overdose, such as trouble breathing, unusually tired or sleepy, or not being able to respond or wake up. Make sure to tell caregivers and close contacts where your naloxone is stored. Make sure they know how to use it. After naloxone is given, the person giving it must call emergency services. Naloxone is a temporary treatment. Repeat doses may be needed.

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This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

This medication will cause constipation. If you do not have a bowel movement for 3 days, call your care team.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

Talk to your care team if you may be pregnant. Prolonged use of this medication during pregnancy can cause temporary withdrawal in a newborn.

Talk to your care team before breastfeeding. Changes to your treatment plan may be needed. If you breastfeed while taking this medication, seek medical care right away if you notice the child has slow or noisy breathing, is unusually sleepy or not able to wake up, or is limp.

Long-term use of this medication may cause infertility. Talk to your care team if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

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  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
  • Low blood sugar (hypoglycemia)—tremors or shaking, anxiety, sweating, cold or clammy skin, confusion, dizziness, rapid heartbeat

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Headache
  • Nausea
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep this medication out of reach of children and pets. Store it out of sight in a safe place. Do not share it with others. Misuse of this medication is dangerous and against the law.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep the container tightly closed. Get rid of any unused medication after the expiration date.

This medication may cause harm and death if it is taken by other adults, children, or pets. It is important to get rid of the medication as soon as you no longer need it or it is expired. To get rid of this medication:

  • Take the medication to a take-back program. Check with your pharmacy or law enforcement to find a location.
  • Follow the steps given to you by your pharmacy. You may be given a pre-paid mail-back envelope or disposal product to safely get rid of your medication.
  • If other options are not available, flush the medication down the toilet.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2025 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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