Acalabrutinib is a medication that stops cancer cells from growing to treat mantle cell lymphoma, chronic lymphocytic leukemia and small lymphocytic lymphoma. This medication comes in a capsule form that you can take by mouth with a glass of water as directed.
ACALABRUTINIB (a KAL a BROO ti nib) treats leukemia and lymphoma. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): CALQUENCE
They need to know if you have any of these conditions:
Take this medication by mouth with a full glass of water. Take it as directed on the prescription label. Do not cut, crush, or chew this medication. Swallow capsules whole. Your care team may change your dose or tell you to stop taking this medication if you get side effects. Do not change your dose or stop taking it unless your care team tells you to.
Do not take this medication with grapefruit juice. Avoid taking H2-blockers and antacids within 2 hours of taking this medication.
Talk to your care team about the use of this medication in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can unless it is more than 3 hours late. If it is more than 3 hours late, skip the missed dose. Take the next dose at the normal time.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your care team for regular checks on your progress. It may be some time before you see the benefit from this medication.
You may need blood work done while you are taking this medication.
This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.
This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.
If you are going to need surgery or other procedure, tell your care team that you are using this medication.
Tell your dentist and dental surgeon that you are taking this medication. You should not have major dental surgery while on this medication. See your dentist to have a dental exam and fix any dental problems before starting this medication. Take good care of your teeth while on this medication. Make sure you see your dentist for regular follow-up appointments.
Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen.
Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancer if you take this medication. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen.
Do not become pregnant while taking this medication or for at least 1 week after stopping it. Talk to your care team if you or your partner wish to become pregnant or think they might be pregnant. This medication can cause serious birth defects. Do not breast-feed while taking this medication or for 2 weeks after stopping it.
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children and pets.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.
To get rid of medications that are no longer needed or have expired:
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.