Ibuprofen Lysine Injection

What is this medication?

IBUPROFEN LYSINE (eye BYOO proe fen LAHY seen) treats a heart defect called patent ductus arteriosus (PDA), an opening between blood vessels near the heart in newborn infants. It works by closing the PDA. It belongs to a group of medications called NSAIDs.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): NeoProfen

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Bleeding problems
• Heart problems
• Infection
• Kidney disease
• Liver disease
• Stomach problems
• An unusual reaction to ibuprofen, other NSAIDs, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

This medication is for infusion into a vein. It is given in a hospital.

This medication is specifically for use in newborns.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medication?

• Aspirin and aspirin-like medications
• Certain antibiotics
• Digoxin
• Diuretics
• Medications that treat or prevent blood clots such as warfarin
• NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
• Steroid medications such as prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your baby's condition will be watched closely while this treatment is given. Your baby will also receive regular blood tests and exams. Talk with your care team if you have any concerns.

This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your healthcare provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
• Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
• Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
• Shortness of breath or trouble breathing

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.