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Dapsone Gel

Dapsone gel is a medication that treats acne. Acne is a common condition that causes pimples on your skin. You can apply this gel to your affected skin as directed, usually once in the morning and once in the evening.

What is this medication?

DAPSONE (DAP sone) treats acne. It works by killing or preventing the growth of bacteria on the skin.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Aczone

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Anemia
  • Glucose 6-phosphate dehydrogenase (G6PD) deficiency
  • An unusual or allergic reaction to dapsone, sulfa medications, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for external use only. Do not take by mouth. Wash your hands before and after use. Do not get it in your eyes. If you do, rinse your eyes with plenty of cool tap water. Use it as directed on the prescription label at the same time every day. Do not use it more often than directed. Use the medication for the full course as directed by your care team, even if you think you are better. Do not stop using it unless your care team tells you to stop it early.

Apply a thin film of the medication to the affected area.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

  • Other acne products

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. It may be some time before you see the benefit from this medication.

If you notice a blue or gray discoloration of the mouth, lips, or nail beds, stop taking this medication and contact your care team.

Some people who have G6PD deficiency may get anemia (low red blood cell levels). Stop taking this medication and contact your care team if you have trouble breathing, feel faint or lightheaded, or are unusually weak or tired.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Burning, itching, crusting, or peeling of treated skin
  • Headache, unusual weakness or fatigue, shortness of breath, nausea, vomiting, rapid heartbeat, blue skin or lips, which maybe signs of methemoglobinemiaSide effects that usually do not require medical attention (report to your care team if they continue or are bothersome):
  • Mild skin irritation, redness, or dryness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Protect from light and moisture. Keep the container tightly closed. Get rid of any unused drug after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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