Copanlisib injection

What is this medication?

COPANLISIB (koe pan lis ib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat follicular non-Hodgkin lymphoma.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Aliqopa

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• diabetes
• infection
• high blood pressure
• liver disease
• lung or breathing disease, like asthma
• an unusual or allergic reaction to copanlisib, other medicines, foods, dyes, or preservative
• pregnant, or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses as directed. It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment

What may interact with this medication?

• antiviral medicines for HIV or AIDS
• boceprevir
• certain medicines for fungal infections like ketoconazole, itraconazole, posaconazole, and voriconazole
• certain medicines for seizures like carbamazepine and phenytoin
• clarithromycin
• conivaptan
• diltiazem
• enzalutamide
• grapefruit juice
• idelalisib
• mitotane
• nefazodone
• rifampin
• St. John's wort
• troleandomycin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

You may need blood work done while you are taking this medication.

This medication may increase your risk of getting an infection. Call your health care provider for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.

Do not become pregnant while taking this medication or for 1 month after stopping it. Women should inform their health care provider if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medication and for 1 month after stopping it. There is a potential for serious harm to an unborn child. Talk to your health care provider for more information. Do not breast-feed an infant while taking this medication or for 1 month after stopping it.

This medication may make it more difficult to get pregnant or father a child. Talk to your health care provider if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• breathing problems
• cough
• headache
• redness, blistering, peeling or loosening of the skin
• signs and symptoms of high blood sugar such as dizziness; dry mouth; dry skin; fruity breath; nausea; stomach pain; increased hunger or thirst; increased urination
• signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
• unusually weak or tired

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

• diarrhea
• mouth sores
• nausea
• pain, tingling, numbness in the hands or feet

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.