Urokinase injection

What is this medication?

UROKINASE (yoor uh KAHY neys) breaks up blood clots. It is used to treat large blood clots formed in the lungs.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Abbokinase, Kinlytic

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

•aneurysm

•bleeding problems or problems with blood clotting

•blood vessel disease or damaged blood vessels

•diabetic retinopathy

•head injury or tumor

•high blood pressure

•infection

•irregular heartbeats

•recent biopsy or surgery

•an unusual or allergic reaction to urokinase, other medicines, foods, dyes, or preservatives

•pregnant or trying to get pregnant

•breast-feeding

How should I use this medication?

This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medication?

Do not take this medicine with any of the following medications:

•aminocaproic acid

•aprotinin

•tranexamic acid

This medicine may also interact with the following medications:

•antiinflammatory drugs, NSAIDs like ibuprofen

•aspirin and aspirin-like medicines

•dipyridamole

•drotrecogin alfa

•fish oil (omega-3 fatty acids) supplements

•ginkgo

•medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine.

This medicine contains albumin from human blood. It may be possible to pass an infection in this medicine. Talk to your doctor about the risks and benefits of this medicine.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Do not take aspirin, ibuprofen, or other nonprescription pain relievers for several days after receiving this medicine.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• blue color to lips or nailbeds
• fast, irregular heartbeat
• signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose
• signs and symptoms of a stroke such as changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm or leg; trouble walking, dizziness, loss of balance or coordination
• trouble passing urine or change in the amount of urine

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• dizziness
• fever
• nausea, vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.