Tesamorelin Injection

What is this medication?

TESAMORELIN (TES a moe REL in) reduces excess fat in the stomach area in people with HIV and lipodystrophy. It works by increasing levels of growth hormone in the body. This reduces the amount of fat stored in the stomach area.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Egrifta

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Cancer
• Diabetes
• Head injury
• Pituitary gland problems, including tumor
• Recent or ongoing head radiation therapy
• Recent surgery or trauma
• An unusual or allergic reaction to tesamorelin, mannitol, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

This medication is injected under the skin. You will be taught how to prepare and give it. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

Do not use this medication if it has solid particles in it, or if it is cloudy or colored. It should be clear and colorless.

A patient package insert for the product will be given to you with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

• Cortisone
• Prednisone
• Ritonavir
• Simvastatin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You may need blood work done while you are taking this medication.

This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.

Talk to your care team about your risk of cancer. You may be more at risk for certain types of cancer if you take this medication.

Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects.

Talk to your care team before breastfeeding. Changes to your treatment plan may be needed.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Joint pain
• Muscle pain or cramps
• Pain, redness, irritation, or bruising at the injection site
• Pain, tingling, or numbness in the hands or feet
• Swelling of the ankles, hands, or feet

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store this medication in the refrigerator. Do not freeze. Keep it in the original container until you are ready to take it. Protect from light. Store the diluent, syringes, and needles at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, ask your pharmacist or care team how to get rid of the medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.