Mannitol Injection

What is this medication?

MANNITOL (MAN i tol) reduces swelling and pressure inside the eye or around the brain. It may also be used to help the body make more urine. It works by helping your kidneys remove more fluid and salt from your blood through the urine. It belongs to a group of medications called diuretics.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Osmitrol

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Bleeding in the brain
• Dehydration
• Fluid in the lungs
• Heart disease
• Kidney disease
• An unusual or allergic reaction to mannitol, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breastfeeding

How should I use this medication?

This medication is infused into a vein. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. While it may be given to children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is not for regular use.

What may interact with this medication?

• Aspirin and aspirin-like medications
• Cisplatin
• Cyclosporine
• Diuretics
• Lithium
• Medications for infection such as acyclovir, adefovir, amphotericin B, bacitracin, cidofovir, foscarnet, ganciclovir, gentamicin, pentamidine, vancomycin
• NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
• Pamidronate
• Zoledronic acid

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake
• Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
• High acid level—trouble breathing, unusual weakness or fatigue, confusion, headache, fast or irregular heartbeat, nausea, vomiting
• High bicarbonate level—confusion, tremors or shaking, feeling faint or lightheaded, nausea, vomiting, muscle spasms, numbness of the face, feet, or hands
• High potassium level—muscle weakness, fast or irregular heartbeat
• High sodium level—confusion, increased thirst, muscle weakness, unusual weakness or fatigue, twitching muscles
• Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
• Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
• Painful swelling, warmth, or redness of the skin, blisters or sores at the infusion site
• Seizures

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

• Pain, redness, or irritation at injection site

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.