Mannitol Injection

Mannitol is a diuretic medication that helps you make more pee to get rid of excess water in your body. A healthcare provider will give you this injection in a hospital or clinic setting. It treats swelling from heart, kidney or liver disease or swelling around your brain or in your eyes. The brand name of this medication is Osmitrol®.

What is this medication?

MANNITOL (MAN i tol) is a diuretic. It helps you make more urine and to lose salt and excess water from your body. It treats swelling from heart, kidney, or liver disease. It also treats swelling around the brain or in the eyes.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Osmitrol

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • bleeding in the brain
  • dehydration
  • fluid in the lungs
  • heart disease
  • kidney disease
  • an unusual or allergic reaction to mannitol, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

This drug is injected into a vein. It is given by a health care provider in a hospital or clinic setting.

Talk to your health care provider about the use of this drug in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

This does not apply. This drug is not for regular use.

What may interact with this medication?

This medicine may interact with the following medications:

  • aspirin and aspirin-like medicines
  • cisplatin
  • cyclosporine
  • diuretics
  • lithium
  • medicines for infection like acyclovir, adefovir, amphotericin B, bacitracin, cidofovir, foscarnet, ganciclovir, gentamicin, pentamidine, vancomycin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • pamidronate
  • zoledronic acid

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • confusion
  • seizures
  • signs and symptoms of electrolyte imbalance like severe diarrhea; unusual sweating; vomiting; loss of appetite; increased thirst
  • signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine
  • signs and symptoms of low potassium like muscle cramps; muscle pain; chest pain; dizziness; feeling faint or lightheaded, falls; palpitations; breathing problems; or fast, irregular heartbeat
  • swelling of the ankles, feet, hands
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dry mouth
  • increased thirst
  • pain, redness or irritation at the site where injected

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This drug is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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