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Deflazacort Tablets

Deflazacort is a corticosteroid medication that treats Duchenne muscular dystrophy. This condition causes skeletal and heart muscle weakness that quickly gets worse with time. You can take this tablet by mouth as directed by either swallowing the tablets whole or crushing them and adding the tablets into soft, wet food.

What is this medication?

DEFLAZACORT (de FLAZ a kort) treats Duchenne muscular dystrophy (DMD), an inherited condition that causes muscle weakness. It works by decreasing inflammation and slowing down an overactive immune system. This helps to maintain muscle strength. It belongs to a group of medications called steroids.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Emflaza

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Cushing's syndrome
  • Diabetes
  • Glaucoma
  • Heart problems or heart disease
  • High blood pressure
  • Infection, such as herpes, measles, chickenpox
  • Kidney disease
  • Liver disease
  • Mental health condition
  • Myasthenia gravis
  • Osteoporosis
  • Seizures
  • Stomach ulcer or intestine disease, such as colitis, diverticulitis
  • Thyroid problem
  • An unusual or allergic reaction to deflazacort, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. Swallow tablets whole. You may crush the tablets and mix with applesauce. Swallow the medication and applesauce right away. Keep taking it unless your care team tells you to stop. If your care team wants you to stop the medication, the dose may be slowly lowered over time to avoid any side effects.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

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Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Carbamazepine
  • Efavirenz
  • Phenytoin
  • Rifampin

This medication may also interact with the following:

  • Clarithromycin
  • Diltiazem
  • Fluconazole
  • Grapefruit juice
  • Medications that relax muscles for surgery
  • Vaccines
  • Verapamil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.

This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bone or joint pain
  • Cushing syndrome—increased fat around the midsection, upper back, neck, or face, pink or purple stretch marks on the skin, thinning, fragile skin that easily bruises, unexpected hair growth
  • High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
  • Increase in blood pressure
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
  • Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
  • Mood and behavior changes—anxiety, nervousness, confusion, hallucinations, irritability, hostility, thoughts of suicide or self-harm, worsening mood, feelings of depression
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Stomach pain that is severe, does not go away, or gets worse
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss

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Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Cough
  • Increase in amount of urine
  • Increase in appetite
  • Runny or stuffy nose
  • Unexpected hair growth
  • Weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, pour the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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