PENICILLAMINE (pen uh SIL uh meen) binds with heavy metals and cystine in the body. It is used to treat Wilson's disease and cystinuria. It is also used to treat rheumatoid arthritis.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Cuprimine, D-PENAMINE, Depen
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
They need to know if you have any of these conditions:
•anemia or other blood disorders
•an unusual or allergic reaction to penicillamine, penicillin, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after food. Do not take with food. Take this medicine at least one hour apart from milk or other medicines. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not skip doses or stop your medicine even if you feel better. Skipping doses for even a few days may cause you to have allergic reactions after restarting this medicine. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Do not take this medicine with any of the following medications:
•medicines for malaria
This medicine may also interact with the following medications:
•certain antacids that contain aluminum, magnesium
•gold compounds used for arthritis
•multi-vitamins with metals, minerals or iron
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your doctor or health care professional for regular check ups. It may take 2 to 3 months to improve your symptoms. Tell your doctor if your symptoms do not improve or if you get any new symptoms. You will need to have important blood work done while on this medicine.
You may need to be on a special diet while taking this medicine. Check with your doctor. Ask if you need to take extra vitamin B6 or a multi-vitamin while taking this medicine.
If you are taking this medicine to prevent kidney stones you need to drink plenty of water. Drink at least 2 full glasses of water at bedtime and 2 more full glasses of water during the night.
If you are going to have surgery, tell your doctor or health care professional that you are taking this medicine.
Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•black, tarry stools
•changes in vision
•fever, chills, sore throat
•numbness, tingling pain
•redness, blistering, peeling or loosening of the skin, including inside the mouth
•swollen or painful glands
•trouble passing urine or change in the amount of urine
•unusual bleeding or bruising
•unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•changes in taste
•loss of appetite
•wrinkled or loose skin
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep the medicine container closed tightly. Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Copyright ©2023 Elsevier Inc. All Rights Reserved.
Note: Introduction and Frequently Asked Questions written and medically approved by Cleveland Clinic professionals.