TNK-tPA (tenecteplase) is an injection that dissolves blood clots in certain blood vessels in your body. Blood clots happen when your blood thickens. A healthcare provider will give you this injection in a hospital or clinic setting.
TENECTEPLASE (TEN neck te place) is used to dissolve blood clots that form in certain blood vessels. This medicine is used when a blood clot in a heart artery causes a heart attack.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): TNKase
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They need to know if you have any of these conditions:
•bleeding problems or problems with blood clotting
•diabetic retinopathy or bleeding problems of the eye
•endocarditis (infection of the heart valves)
•head injury, brain disease, or tumor
•high blood pressure
•recent biopsy, childbirth, surgery, or trauma (injury)
•recent history of stroke
•stomach ulcer or bleeding ulcer
•an unusual or allergic reaction to tenecteplase, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
This does not apply.
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
•antiplatelet drugs such as ticlopidine or clopidogrel
•aspirin and aspirin-like drugs
•medicines that treat or prevent blood clots like warfarin, heparin, enoxaparin, and dalteparin
•NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
You will be closely monitored to check your progress after you receive this medicine. Follow the advice of your doctor or health care professional exactly. You may need bed rest to minimize the risk of bleeding.
This medicine can make you bleed more easily. This effect can last for several days. Try to avoid damage to your teeth and gums when you brush or floss your teeth, and to avoid any other injury to yourself.
Do not take aspirin, ibuprofen, or other nonprescription pain relievers during or for several days after this medicine unless otherwise instructed by your doctor or health care professional.
Side effects that you should report to your doctor or health care professional as soon as possible:
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
This drug is given in a hospital or clinic and will not be stored at home.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
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Note: Introduction and Frequently Asked Questions written and medically approved by Cleveland Clinic professionals.