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Hydroquinone Cream or Gel

Hydroquinone cream is a medicated product that lightens areas of your skin that darkened. Follow the instructions on the label to safely use this product. Make sure you wash your hands before and after using the cream.

What is this medication?

HYDROQUINONE (hahy droh kwi NOHN) treats dark spots on the skin caused by hormones, aging, or sun exposure. It works by decreasing the amount of melanin, a pigment your body makes that gives your skin color. This reduces the appearance of dark spots. Sun prevention measures, including sunscreen, are often combined with this medication. It belongs to a group of medications called skin-lightening agents.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Complex B, Dermarest Skin Correcting Cream Plus, Eldopaque Forte, Eldoquin Forte, EpiQuin Micro, Esoterica, Glyquin, Glyquin XM, Kaxm, Keido, Kexm, Kutea, Kuxm, Lustra, Lustra-AF, Lustra-Ultra, Melanex, Melpaque HP, Melquin HP, Melquin-3, Nava-SC, Nuquin HP, Skin Bleaching, Solaquin Forte

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • An unusual or allergic reaction to hydroquinone, sunscreens, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for external use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after applying. Make sure the skin is clean and dry. Apply just enough to cover the affected area. Rub in gently but completely. Do not apply near the eyes, mouth, or other areas of sensitive skin. If accidental contact occurs, large amounts of water should be used to wash the affected area. If the eyes are involved and eye irritation persists after thoroughly washing, contact your care team. If you are using other skin medications, apply them at different times of the day. Do not use your medication more often than directed.

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Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, apply it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

  • Benzoyl peroxide

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Contact your care team if your condition does not improve in the first 2 months or if you experience too much skin irritation.

This medication will work best if you avoid excessive exposure to sunlight and wear sunscreens and protective clothing. Some hydroquinone products contain sunscreens. Use a sunscreen (SPF 15 or higher). Do not use sun lamps or sun tanning beds/booths. Do not apply to sunburned areas or if you have a skin wound in the area of application.

Most cosmetics, sunscreens, and moisturizing lotions may be worn over this medication. Wait several minutes after application of this medication before applying them.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Burning, itching, crusting, or peeling of treated skin

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Change in skin color
  • Mild skin irritation, redness, or dryness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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