Methenamine; Benzoic Acid; Phenyl Salicylate; Methylene Blue; Hyoscamine Tablets

What is this medication?

METHENAMINE; BENZOIC ACID; PHENYL SALICYLATE; METHYLENE BLUE; HYOSCYAMINE (meth EN a meen; ben zo ik as id; fen il suh LIS uh leyt; METH uh leen bloo; hye oh SYE a meen) relieves symptoms caused by irritation of the urinary tract, such as pain, burning, and passing frequent small amounts of urine. It works by relaxing the muscles of the bladder, which decreases spasms. It is not an antibiotic. It will not treat a urinary tract infection (UTI).

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Hyophen, Prosed DS, RE Methylphen, Urophen MB

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Bladder or prostate problems or trouble passing urine
  • Dehydration
  • Glaucoma
  • Heart disease
  • Kidney disease
  • Liver disease
  • Myasthenia gravis
  • Stomach problems
  • An unusual or allergic reaction to benzoic acid; hyoscyamine; methenamine; methylene blue; phenyl salicylate, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Take your medication at regular intervals. Do not take it more often than directed. Do not stop taking except on your care team's advice.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 7 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

  • Antacids
  • Atropine
  • Antihistamines for allergy, cough and cold
  • Certain antibiotics like sulfacetamide and sulfamethoxazole
  • Certain medications for bladder problems like oxybutynin, tolterodine
  • Certain medications for blood pressure like hydrochlorothiazide, chlorthalidone
  • Certain medications for stomach problems like dicyclomine, hyoscyamine
  • Certain medications for travel sickness like scopolamine
  • Certain medications for Parkinson's disease like benztropine, trihexyphenidyl
  • Ipratropium
  • Ketoconazole
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • Narcotic medications for pain

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

You may need to be on a special diet while taking this medication. Ask your care team how many glasses of water or other fluids to drink each day. Also, ask which foods to include and which to avoid to help keep your urine acidic. Your urine must be acidic for this medication to work.

This medication may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your care team if the problem does not go away or is severe.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blurry vision
  • Change in the amount of urine
  • Fast or irregular heartbeat
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Blue or blue-green urine or stools
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Flushing
  • Nausea
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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