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Phenytoin Suspension

What is this medication?

PHENYTOIN (FEN i toyn) prevents and controls seizures in people with epilepsy. It works by calming overactive nerves in your body.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Dilantin, Dilantin-125

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Alcohol use disorder
  • Asian ancestry
  • Blood disorders or disease
  • Diabetes
  • Heart problems
  • Kidney disease
  • Liver disease
  • Porphyria
  • Recent or ongoing radiation
  • Suicidal thoughts, plans, or attempt by you or a family member
  • Thyroid disease
  • An unusual or allergic reaction to phenytoin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. Shake well before using. Use a specially marked oral syringe, spoon, or dropper to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While it may be prescribed for to children for selected conditions, precautions do apply.

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Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Artemether
  • Certain antivirals for HIV or hepatitis
  • Idelalisib
  • Isavuconazonium
  • Lonafarnib
  • Lorlatinib
  • Lumefantrine
  • Lurasidone
  • Pacritinib
  • Praziquantel
  • Ranolazine

This medication may also interact with the following:

  • Albendazole
  • Alcohol
  • Aspirin and aspirin-like medications
  • Bleomycin
  • Capecitabine
  • Carboplatin
  • Certain medications for blood pressure, heart disease, irregular heartbeat
  • Certain medications for depression, anxiety, or other mental health conditions
  • Certain medications for cholesterol, such as atorvastatin, fluvastatin, simvastatin
  • Certain medications for fungal infections, such as fluconazole, itraconazole, ketoconazole, miconazole, posaconazole, voriconazole
  • Certain medications for seizures, such as carbamazepine, ethosuximide, felbamate, lacosamide, lamotrigine, methsuximide, oxcarbazepine, phenobarbital, topiramate, valproic acid, vigabatrin
  • Certain medications for stomach problems, such as antacids, cimetidine, omeprazole, sucralfate
  • Certain medications that prevent or treat blood clots, such as warfarin, apixaban, dabigatran, edoxaban, and rivaroxaban
  • Chloramphenicol
  • Chlorpropamide
  • Cisplatin
  • Cyclosporine
  • Disulfiram
  • Doxorubicin
  • Doxycycline
  • Estrogen or progestin hormones
  • Fluorouracil
  • Folic acid
  • Irinotecan
  • Isoniazid
  • Medications that relax muscles for surgery
  • Methadone
  • Methotrexate
  • Methylphenidate
  • Paclitaxel
  • Phenothiazines, such as chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • Rifampin
  • St. John's wort
  • Steroid medications such as prednisone or cortisone
  • Sulfadiazine
  • Sulfamethoxazole
  • Teniposide
  • Theophylline
  • Ticagrelor
  • Ticlopidine
  • Tolbutamide
  • Vitamin D

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. This medication needs careful monitoring. Your care team may schedule regular blood tests.

This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms.

Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medication and dosage times.

Do not change brands or dosage forms of this medication without discussing the change with your care team.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

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Estrogen and progestin hormones may not work as well while you are taking this medication. A barrier contraceptive, such as a condom or diaphragm, is recommended if you are using these hormones for contraception. Talk to your care team about effective forms of contraception.

This medication can cause tooth and gum problems. Tenderness, swelling, or minor bleeding of the gums may occur. Brushing and flossing your teeth regularly may reduce the risk of side effects. Visit your dentist on a regular basis. Tell your dentist about any medications you are taking.

Do not take antacids at the same time as this medication. If you get an upset stomach and want to take an antacid or medication for diarrhea, make sure there is an interval of 2 to 3 hours before or after you took your phenytoin.

This medication may cause thoughts of suicide or depression. This includes sudden changes in mood, behaviors, or thoughts. These changes can happen at any time but are more common in the beginning of treatment or after a change in dose. Call your care team right away if you experience these thoughts or worsening depression.

Those who become pregnant while using this medication may enroll in the North American Antiepileptic Drug Pregnancy Registry by calling 1-888-233-2334. This registry collects information about the safety of antiepileptic medication use during pregnancy.

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This medication may cause a decrease in vitamin D and folic acid. You should make sure that you get enough vitamins while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
  • Infection—fever, chills, cough, or sore throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Phenytoin toxicity—uncontrollable eye movements, loss of balance or coordination, trouble speaking, unusual weakness or fatigue, nausea, vomiting
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Slow heartbeat—dizziness, feeling faint or lightheaded, confusion, trouble breathing, unusual weakness or fatigue
  • Swollen lymph nodes in the neck, groin, chest, or underarm area
  • Thoughts of suicide or self-harm, worsening mood, or feelings of depression
  • Unusual bruising or bleeding

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Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Difficulty with paying attention, memory, or speech
  • Dizziness
  • Drowsiness
  • Headache

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not freeze. Protect from light. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2025 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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