Choline Salicylate; Magnesium Salicylate Solution

What is this medication?

CHOLINE SALICYLATE; MAGNESIUM SALICYLATE (KOE leen sa LI si late; mag NEE zhum sa LI si late) treats mild to moderate pain, inflammation, and arthritis. It works by decreasing inflammation. It may also be used to reduce fever. It belongs to a group of medications called NSAIDs.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Trilisate

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Asthma
• Drink more than 3 alcohol-containing drinks a day
• Gout
• Kidney disease
• Liver disease
• Stomach bleeding or ulcers
• An unusual or allergic reaction to choline salicylate, magnesium salicylate, other salicylates, aspirin, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

Take this medication by mouth. Follow the directions on the prescription label. You can mix this medication with fruit juice or water just before taking it. Use a specially marked spoon or container to measure this medication. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take this medication with food if it upsets your stomach. Take your medication at regular intervals. Do not take it more often than directed.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children for selected conditions, precautions do apply.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

• Ketorolac
• Medications that treat or prevent blood clots like warfarin
• Methotrexate
• Probenecid

This medication may also interact with the following:

• Acetazolamide
• Alcohol
• Aspirin and aspirin-like medications
• Medications for diabetes
• Medications for gout
• Methazolamide
• NSAIDs, medications for pain and inflammation, like ibuprofen or naproxen
• Phenytoin
• Steroid medications like prednisone or cortisone
• Sulfinpyrazone
• Valproic acid

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse.

Do not take medications such as ibuprofen and naproxen with this medication. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medications available without a prescription should not be taken with this medication.

This medication can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can happen without warning symptoms and can cause death. To reduce your risk, do not smoke cigarettes or drink alcohol while you are taking this medication.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medication. Avoid alcoholic drinks.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
• Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Ringing in ears

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Heartburn
• Nausea
• Upset stomach
• Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.