Locations:

Choline Salicylate; Magnesium Salicylate Tablets

What is this medication?

CHOLINE SALICYLATE; MAGNESIUM SALICYLATE (KOE leen sa LI si late; mag NEE zhum sa LI si late) treats mild to moderate pain, inflammation, and arthritis. It works by decreasing inflammation. It may also be used to reduce fever. It belongs to a group of medications called NSAIDs.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Tricosal, Trilisate

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Asthma
  • Frequently drink alcohol
  • Gout
  • Heart disease
  • Kidney disease
  • Liver disease
  • Stomach bleeding or ulcers
  • An unusual or allergic reaction to choline salicylate, magnesium salicylate, other salicylates, aspirin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

Take this medication by mouth with a glass of water. Take it as directed on the prescription label at the same time every day. Take this medication with food if it upsets your stomach.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While it may be prescribed for children for selected conditions, precautions do apply.

People 65 years and older may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Ketorolac
  • Medications that treat or prevent blood clots, such as warfarin
  • Methotrexate
  • Probenecid

This medication may also interact with the following:

  • Acetazolamide
  • Alcohol
  • Aspirin and aspirin-like medications
  • Medications for diabetes
  • Medications for gout
  • Methazolamide
  • NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
  • Phenytoin
  • Steroid medications, such as prednisone or cortisone
  • Sulfinpyrazone
  • Valproic acid

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse.

Do not take medications such as ibuprofen and naproxen with this medication. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medications available without a prescription should not be taken with this medication.

This medication can cause serious ulcers and bleeding in the stomach. It can happen with no warning. Tobacco, alcohol, older age, and poor health can also increase risks. Call your care team right away if you have stomach pain or blood in your vomit or stool.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Ringing in ears

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

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  • Heartburn
  • Nausea
  • Upset stomach
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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