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Triptorelin Pamoate Injection Suspension (Prostate Cancer)

Triptorelin is a medication that decreases testosterone to treat prostate cancer. This type of cancer develops in the prostate gland, a part of the male reproductive system. A healthcare provider will give you this injection in a hospital or clinic setting.

What is this medication?

TRIPTORELIN (TRIP toe REH lin) decreases testosterone in men. It is used to treat prostate cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Trelstar, Trelstar Depot, Trelstar LA

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Diabetes (high blood sugar)
  • Heart disease
  • Irregular heartbeat or rhythm
  • Kidney disease
  • Trouble passing urine
  • An unusual or allergic reaction to triptorelin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for injection into a muscle. It is given by a health care provider in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. This medication is not approved for use in children.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

Do not take this medication with any of the following medications:

  • Cisapride
  • Dronedarone
  • Pimozide
  • Thioridazine

This medication may also interact with the following medications:

  • Certain medications for depression, anxiety, or psychotic disturbances
  • Other medications that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication. Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse.

You may need blood work done while you are taking this medicine.

Women should inform their care team if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your care team for more information.

This medication may increase blood sugar. The risk may be higher in patients who already have diabetes. Ask your care team what you can do to lower your risk of diabetes while taking this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Changes in emotions or moods
  • Changes in vision
  • Chest pain
  • Heart rhythm changes— fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • High blood sugar (hyperglycemia)—increased thirst or amount of urine, unusual weakness or fatigue, blurry vision
  • Trouble passing urine or pain when passing urine
  • Unusual weakness

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Change in sex drive or performance
  • Headache
  • Hot flashes
  • Pain, redness, or irritation at injection site

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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