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Hepatitis B Immune Globulin Injection

The HBIG vaccine (hepatitis B immune globulin) prevents infections of the Hepatitis B virus. This virus infects your liver and causes inflammation. A healthcare provider will give you this injection.

What is this medication?

HEPATITIS B IMMUNE GLOBULIN (hep uh TAHY tis B im MUNE GLOB yoo lin) reduces the risk of infections caused by the hepatitis B virus. It is still possible to get hepatitis B after receiving this medication, but the symptoms may be less severe or not last as long. It works by helping your immune system learn how to fight off an infection.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): BayHep B, Hep-B-Gammagee, Hepagam B, HyperHEP B, HyperHEP S/D, Nabi-HB

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Bleeding disorder
  • Low levels of immunoglobulin A in the body
  • Low levels of platelets
  • An unusual or allergic reaction to human immune globulin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is injected into a muscle. HepaGam B may also be infused into a vein. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as newborn for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medication?

Do not take this medication with any of the following:

  • Live virus vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

This medication is made from human blood. It may be possible to pass an infection in this medication. Talk to your care team about the risks and benefits of this medication.

This medication may interfere with live virus vaccines. Before you get other live virus vaccines, tell your care team if you have received this medication within the past 3 months.

Some products can interfere with some types of blood glucose monitoring systems. Talk to your care team if you check your blood sugar.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
  • Infection—fever, chills, cough, or sore throat
  • Infusion reactions—chest pain, shortness of breath or trouble breathing, feeling faint or lightheaded

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Chills
  • Dizziness
  • Fever
  • Headache
  • Muscle pain
  • Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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