Cyclobenzaprine Tablets

Cyclobenzaprine is a medication that relaxes your muscles, which reduces muscle stiffness. It treats muscle spasms. You can take this medication by mouth with a glass of water. You may feel drowsy or dizzy after taking this medication.

What is this medication?

CYCLOBENZAPRINE (sye kloe BEN za preen) treats muscle spasms. It works by relaxing your muscles, which reduces muscle stiffness. It belongs to a group of medications called muscle relaxants.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Fexmid, Flexeril

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Heart disease, irregular heartbeat, or previous heart attack
  • Liver disease
  • Thyroid problem
  • An unusual or allergic reaction to cyclobenzaprine, tricyclic antidepressants, lactose, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. If this medication upsets your stomach, take it with food or milk. Take your medication at regular intervals. Do not take it more often than directed.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • Narcotic medications for cough
  • Safinamide

This medication may also interact with the following:

  • Alcohol
  • Bupropion
  • Antihistamines for allergy, cough and cold
  • Certain medications for anxiety or sleep
  • Certain medications for bladder problems like oxybutynin, tolterodine
  • Certain medications for depression like amitriptyline, fluoxetine, sertraline
  • Certain medications for Parkinson's disease like benztropine, trihexyphenidyl
  • Certain medications for seizures like phenobarbital, primidone
  • Certain medications for stomach problems like dicyclomine, hyoscyamine
  • Certain medications for travel sickness like scopolamine
  • General anesthetics like halothane, isoflurane, methoxyflurane, propofol
  • Ipratropium
  • Local anesthetics like lidocaine, pramoxine, tetracaine
  • Medications that relax muscles for surgery
  • Narcotic medications for pain
  • Phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • Verapamil

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medication. Avoid alcoholic drinks.

If you are taking another medication that also causes drowsiness, you may have more side effects. Give your care team a list of all medications you use. Your care team will tell you how much medication to take. Do not take more medication than directed. Call emergency for help if you have problems breathing or unusual sleepiness.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • CNS depression—slow or shallow breathing, shortness of breath, feeling faint, dizziness, confusion, trouble staying awake
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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