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Chlorhexidine Oral Rinse

Chlorhexidine is a medication that comes as an oral rinse. It treats gingivitis. This is a bacterial gum disease. The oral rinse kills or prevents the growth of bacteria in your mouth and reduces inflammation in your gums.

What is this medication?

CHLORHEXIDINE (klor HEX i deen) treats a bacterial gum disease (gingivitis). It works by killing or preventing the growth of bacteria, which helps to reduce inflammation of your gums.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Oro Clense, Peridex, Periogard, PerioRx, Perisol

What should I tell my care team before I take this medication?

They need to know if you have any of the following conditions:

  • Front tooth fillings, dentures or other mouth appliances, especially those having rough surfaces
  • Other gum or dental problems
  • An unusual or allergic reaction to chlorhexidine, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication should be used immediately after brushing and flossing. Rinse all toothpaste completely from your mouth. Follow the directions on the prescription label. The cap on the original container may be used to measure the dose. If you do not have the cap, ask your pharmacist for a device to measure the dose. Swish the medication in your mouth for 30 seconds. Do not swallow it. Use the medication full strength. Do not mix with water before using. Do not eat or drink for several hours after using the rinse. This may decrease the effect of the medication.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

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NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as possible. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your dentist every 6 months for dental cleanings and to check on your progress.

This medication may have a bitter aftertaste. Do not rinse your mouth after using this medication because that will increase the bitter taste. Rinsing will also decrease the effect of the medication.

This medication may change the way food tastes to you. This effect may last up to 4 hours after using the rinse. Usually this effect becomes less noticeable as you continue using the rinse. Your taste should return to normal after stopping the use of this medication.

This medication may increase tartar build-up and stain your teeth, dentures or fillings. Brush with a tartar control toothpaste and floss daily to help decrease the amount of tartar build-up and staining.

If a child accidentally drinks this medication, get medical attention right away. Small children may have nausea and vomiting and signs of drunkenness.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Pain, irritation, or ulcers in the mouth at application site

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Change in taste
  • Change in tooth color
  • Dry mouth

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep the medication out of reach from children.

Store above 0 degrees C (32 degrees F). Do not freeze. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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