Advertisement
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
PYRIDOSTIGMINE (peer id oh STIG meen) can help with muscle strength. It is used to treat myasthenia gravis.
Advertisement
Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Mestinon
They need to know if you have any of these conditions:
•asthma
•heart disease
•infection in abdomen or peritonitis
•irregular, slow heartbeat
•kidney disease
•seizures
•stomach or bowel obstruction or ulcers
•thyroid disease
•trouble passing urine
•an unusual or allergic reaction to pyridostigmine, bromides, other medicines, foods, dyes, or preservatives
•pregnant or trying to get pregnant
•breast-feeding
Take this medicine by mouth. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
Advertisement
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Do not take this medicine with any of the following medications:
•other medicines for myasthenia gravis like neostigmine
•quinine
This medicine may also interact with the following medications:
•atropine
•bethanechol
•disopyramide
•edrophonium
•guanadrel
•guanethidine
•mecamylamine
•medicines that block muscle or nerve pain
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your doctor or health care professional for regular checks on your progress. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.
Wear a medical ID bracelet or chain, and carry a card that describes your disease and details of your medicine and dosage times.
Side effects that you should report to your doctor or health care professional as soon as possible:
•allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
•breathing problems
•changes in vision
•muscle cramps or spasm
•slow or irregular heartbeat
•stomach cramps or pain
•unusually weak or tired
•vomiting
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
•diarrhea, especially at start of treatment
•increased saliva
•increased sweating
•nausea
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Advertisement
Copyright ©2025 Elsevier Inc. All Rights Reserved.
Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.