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Primaquine Tablets

Primaquine is a medication that prevents malaria infections. Malaria is a serious, sometimes fatal, illness caused by parasites deposited into you by infected mosquitos. You can take these tablets by mouth with a glass of water as directed. Take each dose at regular intervals.

What is this medication?

PRIMAQUINE (PRIM a kwin) prevents and treats malaria. It works by killing the parasite that causes malaria. It will not treat colds, the flu, or infections caused by bacteria or viruses.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Primaquine

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Anemia or other blood disorders
  • Diabetes
  • Glucose 6-phosphate dehydrogenase (G6PD) deficiency
  • Frequently drink alcohol
  • Heart disease
  • High blood pressure
  • History of irregular heartbeat
  • Low levels of magnesium in the blood
  • Low levels of potassium in the blood
  • Lupus
  • Malnutrition
  • Rheumatoid arthritis
  • Thyroid disease
  • An unusual or allergic reaction to primaquine, chloroquine, iodoquinol, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the prescription label at the same time every day. Take all of this medication unless your care team tells you to stop it early. Keep taking it even if you think you are better.

Talk to your care team about the use of this medication in children. While it may be prescribed for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Cisapride
  • Dronedarone
  • Pimozide
  • Quinacrine
  • Thioridazine

This medication may also interact with the following:

  • Grapefruit juice
  • Other medications that cause heart rhythm changes

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

If you are taking this medicine for a long time, visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. If you notice any changes in your vision see your care team for an eye exam.

This medication may affect your coordination, reaction time, or judgement. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

While in areas where malaria is common, you should take steps to prevent being bitten by mosquitos. This includes staying in air-conditioned or well-screened rooms to reduce human-mosquito contact, sleep under mosquito netting, preferably one with pyrethrum-containing insecticide, wear long-sleeved shirts or blouses and long trousers to protect arms and legs, apply mosquito repellents containing DEET to uncovered areas of skin, and use a pyrethrum-containing flying insect spray to kill mosquitos.

If your urine becomes a dark color, tell your care team as soon as you can.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Headache, unusual weakness or fatigue, shortness of breath, nausea, vomiting, rapid heartbeat, blue skin or lips, which may be signs of methemoglobinemia
  • Hemolytic anemia—unusual weakness or fatigue, dizziness, headache, trouble breathing, dark urine, yellowing skin or eyes

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

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  • Dizziness
  • Nausea
  • Stomach pain
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 15 and 30 degrees C (59 and 86 degrees F). Keep the container tightly closed. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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