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Primaquine tablets

Primaquine is a medication that prevents malaria infections. Malaria is a serious, sometimes fatal, illness caused by parasites deposited into you by infected mosquitos. You can take these tablets by mouth with a glass of water as directed. Take each dose at regular intervals.

What is this medication?

PRIMAQUINE (PRIM a kwin) is used to treat or prevent malaria infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Primaquine

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

anemia or other blood disorders

  • diabetes

glucose 6-phosphate dehydrogenase (G6PD) deficiency

  • heart disease
  • high blood pressure
  • history of irregular heartbeat
  • if you drink alcohol
  • low levels of magnesium in the blood
  • low levels of potassium in the blood
  • lupus
  • malnutrition

rheumatoid arthritis

  • thyroid disease

an unusual or allergic reaction to primaquine, chloroquine, iodoquinol, other medicines, foods, dyes, or preservatives

pregnant or trying to get pregnant

breast-feeding

How should I use this medication?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

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What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medicine with any of the following medications:

  • cisapride
  • dronedarone
  • pimozide
  • quinacrine
  • thioridazine

This medicine may also interact with the following medications:

  • grapefruit juice
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm) like dofetilide, ziprasidone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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What should I watch for while using this medication?

Tell your doctor or health care professional if your symptoms do not start to get better in a few days. If you are taking this medicine for a long time, visit your doctor or health care professional for regular checks. If you notice any changes in your vision see your eye doctor for an eye exam.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

While in areas where malaria is common, you should take steps to prevent being bit by mosquitos. This includes staying in air-conditioned or well-screened rooms to reduce human-mosquito contact, sleep under mosquito netting, preferably one with pyrethrum-containing insecticide, wear long-sleeved shirts or blouses and long trousers to protect arms and legs, apply mosquito repellents containing DEET to uncovered areas of skin, and use a pyrethrum-containing flying insect spray to kill mosquitos.

If your urine becomes a dark color, tell your prescriber or health care professional as soon as you can.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

dark urine

hallucination, loss of contact with reality

feeling faint or lightheaded

fever or infection

numbness, tingling

pale, discolored skin

seizures

  • signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat; palpitations; feeling faint or lightheaded, falls; breathing problems

unusual bleeding or bruising

unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

nausea, vomiting

stomach cramps, pain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2024 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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