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Cyclizine Hydrochloride Oral tablet

What is this medication?

CYCLIZINE (SYE kli zeen) prevents and treats nausea, vomiting, and dizziness caused by motion sickness. It works by helping your body maintain its sense of balance. It belongs to a group of medications called antihistamines.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Cyclivert, Marezine

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Glaucoma
  • Kidney disease
  • Liver disease
  • Lung or breathing disease, such as asthma or emphysema
  • Pain or trouble passing urine
  • Prostate trouble
  • Stomach or intestine problems
  • An unusual or allergic reaction to cyclizine, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with water. Take it as directed on the package label. To prevent motion sickness, start taking this medication 30 minutes before you travel. Do not take it more often than directed.

Talk to your care team about the use of this medication in children. While this medication may be used in children as young as 6 years old for selected conditions, precautions do apply.

People over 65 years of age may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

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What may interact with this medication?

This medication may interact with the following medications:

  • Alcohol
  • Medications for sleep
  • Opioid medications for pain
  • Other medications for motion sickness, such as scopolamine
  • Some medications for allergies, cold, or cough

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe.

This medication may cause dry eyes and blurred vision. If you wear contact lenses, you may feel some discomfort. Lubricating drops may help. See your care team if the problem does not go away or is severe.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
  • Trouble passing urine

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Confusion
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 15 and 25 degrees C (59 and 77 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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