Treprostinil injection

What is this medication?

TREPROSTINIL is used to treat pulmonary arterial hypertension. This medicine helps to improve symptoms and quality of life.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Remodulin

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• kidney disease
• liver disease
• an unusual or allergic reaction to treprostinil, epoprostenol, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medication?

This medicine is for infusion under your skin or into a vein via a catheter attached to a portable infusion pump. You will be taught how to prepare and give this medicine. Use exactly as directed. Take your medicine at regular intervals. Do not take your medicine more often than directed.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This medication is given as a continuous infusion, which means that a pump will always be infusing the medication. It is recommended that you have a second pump and start a new infusion at a different site when your first pump is close to running out. Do not stop the infusion for any reason without contacting your care team. Stopping this medication may make your condition much worse.

What may interact with this medication?

This medicine may interact with the following medications:

• certain medicines for blood pressure
• certain medicines that treat or prevent blood clots like warfarin, enoxaparin, dalteparin, apixaban, dabigatran, and rivaroxaban
• diuretics
• gemfibrozil
• rifampin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. You will need to be seen regularly. Report any unusual or severe side effects immediately. If you are having trouble inserting your catheter or using the pump, contact your care team.

Inspect the area around your catheter frequently. Alert your care team if there is any unusual redness, pain, or discharge.

Despite receiving this medication, your condition may worsen, and you may need your dose adjusted. Call your care team if your condition gets worse.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• bruising, pain, or swelling at site where injected
• chest pain
• fast, irregular, or slow heartbeat
• feeling faint or lightheaded, falls
• fever or chills
• pain, tingling, numbness in the hands or feet
• unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• bone or jaw pain
• diarrhea
• flushing
• headache
• nausea, vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store unopened vials between 15 and 25 degrees C (59 and 77 degrees F). A vial of medication should be used no more than 30 days after the initial puncture into the vial. Get rid of any unused medication after the expiration date.

During use of the subcutaneous pump (under the skin), a single syringe of medication can be used for up to 72 hours at 37 degrees C (98.6 degrees F). Get rid of any unused medication after 72 hours.

During use of the intravenous pump (into the vein), this medication can be used for up to 48 hours at 37 degrees C (98.6 degrees F). Get rid of any unused medication after 48 hours.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.