Olmesartan; Amlodipine; Hydrochlorothiazide Tablets

What is this medication?

OLMESARTAN; AMLODIPINE; HYDROCHLOROTHIAZIDE, HCTZ (all mi SAR tan; am LOE di peen; hye droe klor oh THYE a zide) treats high blood pressure. It relaxes your blood vessels and helps your kidneys remove more fluid through the urine, which lowers blood pressure. It is a combination of an ARB, a calcium channel blocker, and a diuretic.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Tribenzor

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Decreased urine
• Diabetes
• Heart failure, recent heart attack, or other heart problems
• If you are on a special diet, like a low salt diet
• Immune system problems, like lupus
• Kidney disease
• Liver disease
• Vomiting or diarrhea as this may cause dehydration
• An unusual or allergic reaction to olmesartan, amlodipine, hydrochlorothiazide, sulfa medications, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label at the same time every day. You can take it with or without food. If it upsets your stomach, take it with food. Keep taking it unless your care team tells you to stop.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

This medication may interact with the following:

• Alcohol
• Barbiturates like phenobarbital
• Diuretics like triamterene, spironolactone, or amiloride
• Lithium
• Medications for blood pressure
• Medications for diabetes
• Norepinephrine
• NSAIDS, medications for pain and inflammation, like ibuprofen or naproxen
• Potassium salts or potassium supplements
• Prescription pain medications
• Skeletal muscle relaxants like tubocurarine
• Some cholesterol lowering medications like cholestyramine or colestipol
• Steroid medications like prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Check your blood pressure as directed. Know what your blood pressure should be and when to contact your care team.

You must not get dehydrated. Ask your care team how much fluid you need to drink a day. Check with your care team if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medication.

Talk to your care team if you wish to become pregnant or think you might be pregnant. This medication can cause serious birth defects.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

This medication may increase blood sugar. Ask your care team if changes in diet or medications are needed if you have diabetes.

Avoid salt substitutes unless you are told otherwise by your care team.

Talk to your care team about your risk of skin cancer. You may be more at risk for skin cancer if you take this medication.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Do not treat yourself for coughs, colds, or pain while you are taking this medication without asking your care team for advice. Some ingredients may increase your blood pressure.

If you are going to have surgery or dialysis, tell your care team that you are taking this medication.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
• Gout—severe pain, redness, warmth, or swelling in joints, such as the big toe
• Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
• High potassium level—muscle weakness, fast or irregular heartbeat
• Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
• Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision
• Low potassium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, constipation
• Severe diarrhea
• Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
• Worsening chest pain (angina)—pain, pressure, or tightness in the chest, neck, back, or arms

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Change in sex drive or performance
• Constipation
• Facial flushing, redness
• Fatigue
• Headache
• Stomach pain
• Swelling of the ankles, hands, or feet

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.