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Floxuridine Injection

What is this medication?

FLOXURIDINE (flox YOOR i deen) treats colorectal cancer and liver cancer. It works by slowing down the growth of cancer cells.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): FUDR

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Blood disorders
  • Infection, such as chickenpox, cold sores, herpes
  • Kidney disease
  • Liver disease
  • Poor nutrition
  • Recent or ongoing radiation therapy
  • An unusual or allergic reaction to floxuridine, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is injected into an artery in the liver. It is given by your care team in a hospital or clinic setting.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

Keep appointments for follow-up doses. It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

What may interact with this medication?

Do not take this medication with any of the following:

  • Live virus vaccines

This medication may also interact with the following:

  • Allopurinol
  • Certain medications for seizures, such as ethotoin, fosphenytoin, phenytoin
  • Certain other chemotherapy medications, such as busulfan, cisplatin, estramustine, vinblastine
  • Cimetidine
  • Digoxin
  • Dipyridamole
  • Hydroxyurea
  • Leucovorin
  • Medications to increase blood counts, such as filgrastim, pegfilgrastim, sargramostim
  • Methotrexate
  • Metronidazole
  • NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen

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This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

This medication may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your care team tells you to stop.

In some cases, you may be given additional medications to help with side effects. Follow all directions for their use.

Do not treat diarrhea with over the counter products. Contact your care team if you have diarrhea that lasts more than 2 days or if it is severe and watery.

This medication may increase your risk of getting an infection. Call your care team for advice if you get a fever, chills, sore throat, or other symptoms of a cold or flu. Do not treat yourself. Try to avoid being around people who are sick.

This medication may increase your risk to bruise or bleed. Call your care team if you notice any unusual bleeding.

Be careful brushing or flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medication.

Avoid taking medications that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your care team. These medications may hide a fever.

Talk to your care team if you wish to become pregnant or think you are pregnant. This medication can cause serious birth defects if taken during pregnancy. A reliable form of contraception is recommended while taking this medication. Talk to your care team about effective forms of contraception.

Do not breastfeed while taking this medication.

This medication may cause infertility. Talk to your care team if you are concerned about your fertility.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Bleeding—bloody or black, tar-like stools, vomiting blood or brown material that looks like coffee grounds, red or dark brown urine, small red or purple spots on skin, unusual bruising or bleeding
  • Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
  • Pain, redness, or swelling with sores inside the mouth or throat

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Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Hair loss
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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