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Enalaprilat Injection

What is this medication?

ENALAPRILAT (e NAL a pril at) treats high blood pressure. It works by relaxing blood vessels, which decreases the amount of work the heart has to do. It belongs to a group of medications called ACE inhibitors.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Vasotec

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Autoimmune conditions, such as lupus
  • Diet low in salt
  • Heart or blood vessel conditions
  • Kidney disease
  • Liver disease
  • Low blood pressure
  • Previous swelling of the tongue, face, or lips with trouble breathing, trouble swallowing, hoarseness, or tightening of the throat
  • An unusual or allergic reaction to enalaprilat, other ACE inhibitors, insect venom, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

This medication is injected into a vein. It is given in a hospital or clinic.

Talk to your care team about the use of this medication in children. While it may be prescribed for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. This medication is given in a hospital or clinic.

What may interact with this medication?

Do not take this medication with any of the following:

  • Sacubitril; valsartan

This medication may also interact with the following:

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  • Diuretics
  • Lithium
  • NSAIDs, medications for pain and inflammation, such as ibuprofen or naproxen
  • Other medications for high blood pressure
  • Potassium salts or supplements

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medication.

This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects.

Discuss this medication with your care team if you may be pregnant. Serious birth defects can occur if you take this medication during the second and third trimesters. Discuss other treatment options with your care team. There are benefits and risks to taking medications during pregnancy. Your care team can help you find the option that works for you.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • High potassium level—muscle weakness, fast or irregular heartbeat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Cough
  • Dizziness
  • Headache
  • Nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic. It will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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