Ixazomib oral capsules

Ixazomib is a medication that stops cancer cells from growing to treat multiple myeloma. This type of cancer can affect your bones, your kidneys and your body’s ability to make healthy red and white blood cells and platelets. This medication comes as a capsule that you can take by mouth as directed.

What is this medication?

IXAZOMIB (ix az oh mib) is a medicine that targets proteins in cancer cells and stops the cancer cells from growing. It is used to treat multiple myeloma.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): NINLARO

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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • kidney disease or on hemodialysis
  • liver disease
  • an unusual or allergic reaction to ixazomib, or other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

Take this medicine by mouth. Take it exactly as directed on the prescription label. Take it on the same day and at the same time of each week. Taking it more often than directed can cause serious side effects. Keep taking this unless your health care provider tells you to stop.

Take this medicine on an empty stomach, at least 1 hour before or 2 hours after food. Do not take at the same time as dexamethasone. Do not cut, crush or chew this medicine.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

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NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 72 hours, then do not take the missed dose. Take the next dose at your regular time. If you vomit after taking your medicine, do not take another dose. Take the next dose at your regular time. Do not take double or extra doses.

What may interact with this medication?

This medicine may interact with the following medications:

  • carbamazepine
  • phenytoin
  • rifampin
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  • St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Your condition will be monitored carefully while you are receiving this medicine. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

You may need blood work done while you are taking this medicine.

Do not become pregnant while taking this medicine or for 90 days after stopping it. Women must use a non-hormonal form of birth control while taking this medicine. Men should not father a child while taking this medicine and for 90 days after stopping it. There is potential for serious harm to an unborn child. Tell your health care provider right away if you think you might be pregnant. Do not breast-feed an infant while taking this medicine or for 90 days after stopping it.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • changes in vision
  • confusion
  • constipation
  • decreased urination
  • diarrhea
  • dizziness
  • fast, irregular heartbeat
  • muscle weakness
  • nausea/vomiting
  • pain, tingling, numbness in the hands or feet
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • shortness of breath
  • signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin
  • swelling of the ankles, feet, hands
  • unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • back pain
  • blurred vision

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children.

Store in original packaging at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Copyright ©2023 Elsevier Inc. All Rights Reserved.

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Note: Introduction and Frequently Asked Questions written and medically approved by Cleveland Clinic professionals.

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