Conjugated Estrogens Injection

What is this medication?

CONJUGATED ESTROGENS (CON ju gate ed ESS troe jenz) treats vaginal bleeding caused by low levels of estrogen. It is often used for a short period of time. It works by increasing levels of the hormone estrogen in the body. This medication is an estrogen hormone.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Premarin

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Blood vessel disease, blood clotting disorder, or suffered a stroke
• Breast, cervical, endometrial, ovarian, or uterine cancer
• Dementia
• Gallbladder disease
• Heart disease
• High blood levels of calcium
• Kidney disease
• Liver disease
• Protein C deficiency
• Protein S deficiency
• Vaginal bleeding
• An unusual or allergic reaction to estrogens, other hormones, medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

This medication is for injection into a vein, or injection into a muscle. It is given in a hospital or clinic setting.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medication?

Do not take this medication with any of the following:

• Exemestane

This medication may also interact with the following:

• Barbiturates or benzodiazepines used for inducing sleep or treating seizures (convulsions)
• Carbamazepine
• Grapefruit juice
• Medications for fungal infections, such as ketoconazole and itraconazole
• Raloxifene or tamoxifen
• Rifabutin, rifampin, or rifapentine
• Ritonavir
• Some antibiotics used to treat infections
• St. John's Wort
• Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

This medication can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your care team if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medication right away and contact your care team.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medication, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you are going to have surgery, you may need to stop taking this medication. Consult your care team for advice before you schedule the surgery.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
• Blood clot—pain, swelling, or warmth in the leg, shortness of breath, chest pain
• Breast tissue changes, new lumps, redness, pain, or discharge from the nipple
• Gallbladder problems—severe stomach pain, nausea, vomiting, fever
• Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
• Heavy vaginal bleeding
• Increase in blood pressure
• Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision
• Sudden eye pain or change in vision such as blurry vision, seeing halos around lights, vision loss
• Unusual vaginal discharge, itching, or odor

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Bloating
• Breast pain or tenderness
• Dark patches of skin on the face or other sun-exposed areas
• Hair loss
• Nausea
• Stomach pain
• Swelling of the ankles, hands, or feet

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This medication is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.