Locations:

Azithromycin Immediate-Release Suspension

What is this medication?

AZITHROMYCIN (az ith roe MYE sin) treats infections caused by bacteria. It belongs to a group of medications called antibiotics. It will not treat colds, the flu, or infections caused by viruses.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Zithromax, Zithromax Powder, Zithromax Single-Dose

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • History of blood diseases, such as leukemia
  • History of irregular heartbeat
  • Kidney disease
  • Liver disease
  • Myasthenia gravis
  • An unusual or allergic reaction to azithromycin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breastfeeding

How should I use this medication?

Take this medication by mouth. Take it as directed on the prescription label.

For the suspension already mixed by the pharmacist: Shake well before using. This medication can be taken with food or on an empty stomach. If the medication upsets your stomach, take it with food. Use a specially marked oral syringe, spoon, or dropper to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medication at regular intervals. Do not take your medication more often than directed. Take all of this medication unless your care team tells you to stop it early. Keep taking it even if you think you are better. There may be unused or extra doses in the bottle after you finish the full course of antibiotics. Talk to your care team if you have questions about your dose.

Advertisement

For the 1 gram single dose packet: This medication can be taken with food or on an empty stomach. Empty the contents of a single dose packet into two ounces of water (about one quarter of a full glass). Mix and drink all the mixture at once. Add another two ounces of water to the glass, mix well and drink all of it, to make sure you take the full dose.

Talk to your care team about the use of this medication in children. While it may be prescribed for infants as young as 6 months for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

  • Cisapride
  • Dronedarone
  • Pimozide
  • Thioridazine

This medication may also interact with the following:

  • Antacids that contain aluminum or magnesium
  • Colchicine
  • Cyclosporine
  • Digoxin
  • Ergot alkaloids, such as dihydroergotamine, ergotamine
  • Estrogen or progestin hormones
  • Nelfinavir
  • Other medications that cause heart rhythm changes
  • Phenytoin
  • Warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Tell your care team if your symptoms do not start to get better or if they get worse.

This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

Do not treat diarrhea with over the counter products. Contact your care team if you have diarrhea that lasts more than 2 days or if it is severe and watery.

Contact your care team if vomiting and fussiness with feeding occurs in a treated infant.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Advertisement

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching, hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Severe diarrhea, fever
  • Unusual vaginal discharge, itching, or odor

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Nausea
  • Stomach pain
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store between 5 and 30 degrees C (41 and 86 degrees F) for up to 10 days. Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Advertisement

Advertisement

Copyright ©2025 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

Ad