Isoniazid Injection

What is this medication?

ISONIAZID (eye soe NYE a zid) prevents and treats tuberculosis (TB), an infection caused by bacteria. It belongs to a group of medications called antibiotics. It will not treat colds, the flu, or infections caused by viruses.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Nydrazid

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

• Diabetes
• Frequently drink alcohol
• HIV or AIDs
• Kidney disease
• Liver disease
• Poor nutrition
• Tingling of the fingers or toes or other nerve disorder
• An unusual or allergic reaction to isoniazid, other medications, foods, dyes, or preservatives
• Pregnant or trying to get pregnant
• Breast-feeding

How should I use this medication?

This medication is injected into a muscle. It is usually given by your care team in a hospital or clinic setting. It may also be given at home.

If you get this medication at home, you will be taught how to prepare and give it. Take each dose exactly as prescribed on the prescription label. Do not skip doses. Skipping doses can make the infection resistant to this and other medications. You may also spread the infection to others. Keep taking this medication unless your care team tells you to stop. Your care team may have someone watch you take each dose. This can help you manage your treatment.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following:

• Atomoxetine
• Mavacamten

This medication may also interact with the following:

• Acetaminophen
• Alcohol
• Medications for fungal infections, such as ketoconazole and itraconazole
• Medications for seizures, such as carbamazepine, phenytoin, valproic acid
• Theophylline

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. Tell your care team if your symptoms do not start to get better or if they get worse. You will need blood work done regularly.

Drinking alcohol with this medication can increase the risk of side effects.

You should make sure you get enough vitamin B6 and vitamin D while you are taking this medication. Discuss the food you eat and the vitamins you take with your care team.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

• Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
• Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
• Pain, tingling, or numbness in the hands or feet

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

• Nausea
• Pain, redness, or irritation at injection site
• Stomach pain
• Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

You will be instructed on how to store this medication. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

• Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
• If you cannot return the medication, ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.