Locations:

Clindamycin; Benzoyl Peroxide Gel or Lotion

What is this medication?

CLINDAMYCIN; BENZOYL PEROXIDE (klin da MYE sin; BEN zoe ill per OX ide) treats acne. It works by killing or preventing the growth of bacteria that cause acne. It is a combination of an antibiotic and an antiseptic.

Advertisement

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Acanya, BenzaClin, Duac, Duac CS, Neuac, ONEXTON

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Having surgery
  • Inflammatory bowel disease, such as Crohn's disease or ulcerative colitis
  • An unusual or allergic reaction to benzoyl peroxide, clindamycin, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

This medication is for external use only. Do not take by mouth. Wash your hands before and after use. Do not get it in your eyes. If you do, rinse your eyes with plenty of cool tap water. Use it as directed on the prescription label. Do not use it more often than directed. Use the medication for the full course as directed by your care team, even if you think you are better. Do not stop using it unless your care team tells you to stop it early.

Clean the affected area of skin and pat it dry. Apply a thin film of the medication to the affected area.

Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 12 years for selected conditions, precautions do apply.

Advertisement

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

  • Erythromycin
  • Medications that relax muscles for surgery
  • Other topical medications

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress. It may be some time before you see the benefit from this medication.

This medication can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and sunscreen. Do not use sun lamps or tanning beds/booths.

This medication may cause white fabric to turn yellow. Wash yellowed fabrics with laundry detergent.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Burning, itching, crusting, or peeling of treated skin
  • Severe diarrhea, fever

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Change in hair color
  • Mild skin irritation, redness, or dryness
  • Sensitivity to light

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

See product for storage information. Each product may have different instructions.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

Advertisement

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Advertisement

Copyright ©2025 Elsevier Inc. All Rights Reserved.

Terms of use.

Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

Ad