Lidocaine; Prilocaine cream

What is this medication?

LIDOCAINE; PRILOCAINE (LYE doe kane; PRIL oh kane) is a topical anesthetic that causes loss of feeling in the skin and surrounding tissues. It is used to numb the skin before procedures or injections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): ANODYNE LPT, DermacinRx, DermacinRx Prizopak, EMLA, IV Novice Pack, Leva Set, Lido-Prilo Caine, Lidotor, LiProZonePak, LIVIXIL Pak, LP Lite Pak, Medolor Pak with Tegaderm Dressing, Microvix LP, Nuvakaan, Nuvakaan-II, Port-Prep, PrepIV, PRILOHEAL PLUS 30, Prilovix, Prilovix Lite, Prilovix Lite Plus, Prilovix Plus, Prilovix Ultralite, Prilovix Ultralite Plus, Prilovixil, Prizopak-II, REAL HEAL-I, Relador, Soluline, SOLUPICC, VallaDerm-90


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What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • G6PD deficiency
  • heart disease
  • kidney disease
  • liver disease
  • skin conditions or sensitivity
  • an unusual or allergic reaction to lidocaine, prilocaine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medication?

This medicine is for external use only on the skin. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. Do not use more or leave in contact with the skin longer than directed. Do not apply to eyes or open wounds. It can cause irritation and blurred or temporary loss of vision. If this medicine comes in contact with your eyes, immediately rinse the eye with water. Do not touch or rub the eye. Contact your health care provider right away.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.


What if I miss a dose?

This medicine is usually only applied once prior to each procedure. It must be in contact with the skin for a period of time for it to work. If you applied this medicine later than directed, tell your health care professional before starting the procedure.

What may interact with this medication?

This medicine may interact with the following medications:

  • acetaminophen
  • certain antibiotics like dapsone, nitrofurantoin, aminosalicylic acid, sulfasalazine
  • certain medicines for seizures like phenobarbital, phenytoin, valproic acid
  • chloroquine
  • cyclophosphamide
  • flutamide
  • hydroxyurea
  • ifosfamide
  • metoclopramide
  • nitroglycerin
  • other local anesthetics like pramoxine, tetracaine
  • primaquine
  • quinine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.


What should I watch for while using this medication?

Be careful to avoid injury to the treated area while it is numb and you are not aware of pain. Avoid scratching, rubbing, or exposing the treated area to hot or cold temperatures until complete sensation has returned. The numb feeling will wear off a few hours after applying the cream.

What side effects may I notice from receiving this medication?

Side effects that you should report to your doctor or health care professional as soon as possible:

•blurred vision

•chest pain

•difficulty breathing



•fast or irregular heartbeat

•skin rash or itching

•swelling of your throat, lips, or face


Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

•changes in ability to feel hot or cold

•redness and swelling at the application site

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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