What is this medication?

ABACAVIR; DOLUTEGRAVIR; LAMIVUDINE (a ba KA vir; doe loo teg ra veer; la MI vyoo deen) is 3 antiretroviral medications in 1 tablet. It helps manage infections caused by HIV. It is not a cure for HIV.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): TRIUMEQ

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Heart disease
  • If you often drink alcohol
  • Kidney disease
  • Liver disease
  • Smoke tobacco
  • An unusual or allergic reaction to abacavir, dolutegravir, lamivudine, other medications, lactose, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Take this medication by mouth with water. Do not cut, crush or chew this medication. Swallow the tablets whole. You can take it with or without food. If it upsets your stomach, take it with food. For your therapy to work as well as possible, take each dose exactly as prescribed on the prescription label. Do not skip doses. Skipping doses can make the HIV resistant to this and other medications. Keep taking this therapy unless your care team tells you to stop.

Take sucralfate, buffered medications, and antacid and laxative products with aluminum or magnesium in them at a different time of day than this medication. Take this medication 2 hours BEFORE or 6 hours AFTER these products.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your care team about the use of this medication in children. While it may be given to children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medication?

Do not take this medication with any of the following medications:

  • Any other medication that contains abacavir or lamivudine
  • Any medication that contains emtricitabine
  • Dofetilide

This medication may also interact with the following medications:

  • Alcohol or alcohol containing products
  • Antiviral medications for HIV or AIDS like efavirenz, etravirine, nevirapine, fosamprenavir/ritonavir, tipranavir/ritonavir
  • Buffered medications, like buffered aspirin
  • Calcium supplements
  • Certain antacids
  • Certain laxatives
  • Certain medications for seizures like carbamazepine, oxcarbazepine, phenytoin, phenobarbital
  • Interferon
  • Iron supplements
  • Metformin
  • Methadone
  • Nelfinavir
  • Ribavirin
  • Rifampin
  • Sorbitol
  • St. John's Wort; Hypericum perforatum
  • Sucralfate
  • Sulfamethoxazole; trimethoprim, SMX-TMP

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular check-ups. Discuss any new symptoms with your care team. You will need to have important blood work done while on this medication.

HIV is spread to others through sexual or blood contact. Talk to your care team about how to stop the spread of HIV.

If you have hepatitis B, talk to your care team if you plan to stop this medication. The symptoms of hepatitis B may get worse if you stop this medication.

A small number of people may have a severe allergy to this medication. Some symptoms are a skin rash, fever, nausea, vomiting, stomach pain, severe tiredness, aches, or generally feeling sick. A list of these symptoms is on the Warning Card given to you by your pharmacist. You should carry this Warning Card with you. If you have these symptoms while taking this medication, stop the medication and call your care team right away.

If you stop this medication because you ran out of medication or because you may have had an allergic reaction, talk to your care team. Do not restart this medication without your care team's advice. Severe hypersensitivity reactions can occur within hours and may include life-threatening hypotension and death.

Do not become pregnant while taking this medication. Women should inform their care team if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your care team for more information.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded
  • High lactic acid level—muscle pain or cramps, stomach pain, trouble breathing, general discomfort and fatigue
  • Infection—fever, chills, cough, or sore throat
  • Liver injury—right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Diarrhea
  • Fatigue
  • Headache
  • Trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Protect from moisture. Keep the container tightly closed. Do not throw out the packet in the container. It keeps the medication dry. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, take the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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